All Phenotypes E2f4<tm2.1Lees> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

E2f4^tm2.1Lees
targeted mutation 2.1, Jacqueline A Lees
MGI:5706731

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	E2f4^tm2.1Lees/E2f4^tm2.1Lees E2f5^tm1Dli/E2f5⁺ Tg(Vil1-cre)20Syr/0	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2	MGI:5706798
cn2	E2f4^tm2.1Lees/E2f4^tm2.1Lees Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6	MGI:5904345
cn3	E2f4^tm2.1Lees/E2f4^tm2.1Lees Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6	MGI:5904347
cn4	E2f4^tm2.1Lees/E2f4^tm2.1Lees Tg(Vil1-cre)20Syr/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:5706796
cx5	E2f4^tm2.1Lees/E2f4^tm2.1Lees E2f5^tm1Dli/E2f5^tm1Dli	involves: 129S1/Sv * 129S4/SvJae * C57BL/6	MGI:5706800
cx6	E2f4^tm2.1Lees/E2f4⁺ E2f5^tm1Dli/E2f5^tm1Dli	involves: 129S1/Sv * 129S4/SvJae * C57BL/6	MGI:5706801

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees E2f5^tm1Dli/E2f5⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
E2f5^tm1Dli mutation (1 available); any E2f5 mutation (13 available)
Tg(Vil1-cre)20Syr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:228346 )

N	• male mice exhibit normal spermatogenesis

dilated rete testis ( J:228346 )

• often contains many spermatozoa

abnormal seminiferous tubule epithelium morphology ( J:228346 )

• atrophic

dilated seminiferous tubule ( J:228346 )

• with dilation at that the expense of the epithelium

abnormal efferent ductules of testis morphology ( J:228346 )

• spermatozoa accumulate in the efferent ducts unlike in wild-type mice

• efferent duct epithelium lacks multiciliated cells and exhibit decreased abundance of endocytic vesicle apparatus

abnormal epididymis morphology ( J:228346 )

• no spermatozoa are detected in the epididymis

male infertility ( J:228346 )

endocrine/exocrine glands

dilated rete testis ( J:228346 )

• often contains many spermatozoa

abnormal seminiferous tubule epithelium morphology ( J:228346 )

• atrophic

dilated seminiferous tubule ( J:228346 )

• with dilation at that the expense of the epithelium

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiratory motile cilium morphology ( J:241925 )

• mice treated with 4-hydroxytamoxifen show disruption of multiciliogenesis in lung epithelium

• 4-hydroxytamoxifen treated mice are unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

cellular

abnormal respiratory motile cilium morphology ( J:241925 )

• mice treated with 4-hydroxytamoxifen show disruption of multiciliogenesis in lung epithelium

• 4-hydroxytamoxifen treated mice are unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiratory motile cilium morphology ( J:241925 )

• mice are unable to form multiciliated cells and unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

cellular

abnormal respiratory motile cilium morphology ( J:241925 )

• mice are unable to form multiciliated cells and unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Tg(Vil1-cre)20Syr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:228346 )

• mice are viable and fertile with normal intestinal morphology and efferent duct epithelium

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees E2f5^tm1Dli/E2f5^tm1Dli
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

dilated rete testis ( J:228346 )

• in all mice

abnormal efferent ductules of testis morphology ( J:228346 )

• at 3 weeks, efferent duct epithelium exhibit reduced multiciliated cells compared with control mice

endocrine/exocrine glands

dilated rete testis ( J:228346 )

• in all mice

Allelic Composition	E2f4^tm2.1Lees/E2f4⁺ E2f5^tm1Dli/E2f5^tm1Dli
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

dilated rete testis ( J:228346 )

• in all mice

abnormal efferent ductules of testis morphology ( J:228346 )

• at 3 weeks, efferent duct epithelium exhibit reduced multiciliated cells compared with control mice

endocrine/exocrine glands

dilated rete testis ( J:228346 )

• in all mice

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