Analysis Tools
mortality/aging
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• homozygous embryos are recovered at expected Mendelian ratios at E7.5 but arrest prior to gastrulation
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• no homozygous embryos are recovered at E9.5
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embryo
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• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
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• embryos arrest prior to gastrulation
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• embryos are much smaller than controls at E7.5
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• a rudimentary egg cylinder is observed at E7.5
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• no head folds are present at E7.5
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• no embryonic node is present at E7.5
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• no morphological evidence of primitive streak formation is observed at E7.5
• no Brachyury (T)-positive cells are present at E7.5, suggesting failure of primitive streak initiation
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growth/size/body
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• embryos are much smaller than controls at E7.5
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