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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prtn3tm1.1Hrlu
targeted mutation 1.1, Hongbo R Luo
MGI:5705568
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prtn3tm1.1Hrlu/Prtn3tm1.1Hrlu involves: C57BL/6 MGI:5707642


Genotype
MGI:5707642
hm1
Allelic
Composition		 Prtn3tm1.1Hrlu/Prtn3tm1.1Hrlu
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prtn3tm1.1Hrlu mutation (0 available); any Prtn3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased neutrophil cell number ( J:217636 )
• significantly increased numbers of annexin V - neutrophils
abnormal neutrophil physiology ( J:217636 )
• mice infected peritonealy with E. coli show the expected rapid rise in neutrophil number but the subsequent decline in neutrophil number is attenuated
• decreased percentage of apoptotic neutrophils in late stages of acute infections

cellular
decreased apoptosis ( J:217636 )
• decreased percentage of apoptotic neutrophils in late stages of acute infections

immune system
increased neutrophil cell number ( J:217636 )
• significantly increased numbers of annexin V - neutrophils
abnormal neutrophil physiology ( J:217636 )
• mice infected peritonealy with E. coli show the expected rapid rise in neutrophil number but the subsequent decline in neutrophil number is attenuated
• decreased percentage of apoptotic neutrophils in late stages of acute infections




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory