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Allele Symbol Allele Name Allele ID |
Gabra1tm1.1Mjga targeted mutation 1.1, Martin J Gallagher MGI:5705517 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice at P120 exhibit a discharge that starts with two or more consecutive spikes and/or waves and occurs with an irregular periodicity and a high frequency, features resembling polyspike-and-wave discharges
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
• spontaneous polyspike-and-wave discharges are more frequent at P120 than P35
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• seizures in P120 mutants occur with a higher probability at shorter latencies after PTZ injection than in wild-type mice
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• 10% of polyspike-and-wave discharges are associated with visible myoclonic jerks
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
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• one spontaneous generalized tonic-clonic seizure was recorded in one P120 mouse
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• mice exhibit absence-like seizures at P35 and P120
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• mice exhibit abundant spike-wave discharges (SWDs) at P35 and P120
• each SWD consists of very rhythmic, 6-8 Hz spikes, positive transients, and waves
• SWDs are associated with behavioral arrest
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• 10% of polyspike-and-wave discharges are associated with visible myoclonic jerks
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
|
|
• mice at P120 exhibit a discharge that starts with two or more consecutive spikes and/or waves and occurs with an irregular periodicity and a high frequency, features resembling polyspike-and-wave discharges
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
• spontaneous polyspike-and-wave discharges are more frequent at P120 than P35
|
|
• seizures in P120 mutants occur with a higher probability at shorter latencies after PTZ injection than in wild-type mice
|
|
• 10% of polyspike-and-wave discharges are associated with visible myoclonic jerks
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
|
|
• one spontaneous generalized tonic-clonic seizure was recorded in one P120 mouse
|
|
• mice exhibit absence-like seizures at P35 and P120
|
|
• mice exhibit abundant spike-wave discharges (SWDs) at P35 and P120
• each SWD consists of very rhythmic, 6-8 Hz spikes, positive transients, and waves
• SWDs are associated with behavioral arrest
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• reduction in mIPSC amplitudes and increase in the time course of current decay in P35 and P120 cortices
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| idiopathic generalized epilepsy | DOID:1827 |
OMIM:600669 |
J:227437 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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