Phenotypes associated with this allele

• Allele Symbol: Mrln^em1Eno
• Allele Name: endonuclease-mediated mutation 1, Eric N Olson
• Allele ID: MGI:5705514
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrln^em1Eno/Mrln^em1Eno	involves: C3H * C57BL/6	MGI:5755519

Genotype
MGI:5755519

hm1

• Allelic Composition: Mrln^em1Eno/Mrln^em1Eno
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle physiology ( J:217579 )

• homozygotes show improved exercise performance and enhanced Ca²⁺ handling in skeletal muscle relative to wild-type controls

• however, skeletal muscle weights are normal and no obvious differences in fiber-type identity or myofiber size are detected in quadriceps (fast-type), gastrocnemius, and soleus muscles (slow-type) relative to wild-type controls

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:217579 )

• in vitro, primary myoblasts isolated from hindlimb muscles imaged using Fura-2-AM and treated with the RyR agonist 4-CMC show significantly increased SR Ca²⁺ levels relative to wild-type myoblasts, measured as peak Ca²⁺ release from the sarcoplasmic reticulum

enhanced exercise endurance ( J:217579 )

• when subjected to forced treadmill running to exhaustion, 8-wk-old homozygotes run ~31% longer than wild-type controls, representing a 55% increase in running distance