All Phenotypes Alk<tm1.1Ics> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Alk^tm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5705324

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Alk^tm1.1Ics/? Tg(Th-MYCN)41Waw/0	involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J	MGI:5789375
ot2	Alk^tm1.1Ics/?	involves: 129S2/SvPas * C57BL/6	MGI:5789371

Allelic Composition	Alk^tm1.1Ics/? Tg(Th-MYCN)41Waw/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alk^tm1.1Ics mutation (0 available); any Alk mutation (62 available)
Tg(Th-MYCN)41Waw mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased neuroblastoma incidence ( J:228124 , J:261033 )

• tumors are classified as neuroblastoma, stroma-poor, poorly differentiated or differentiating (J:228124)

• tumor onset occurs later than in mice carrying the Alk^tm2.1Ics allele (J:228124)

• abdominal tumors are median, perivascular and locally invasive without evidence of macroscopic tumor spread to other organs (J:228124)

• tumors at 2 or 3 locations (abdominal/thoracic/cervical) are seen in 70% of mice (J:228124)

• mice treated with vandetanib, a kinase inhibitor, or crizotinib, show a reduction in abdominal tumor weight (J:228124)

mortality/aging

premature death ( J:261033 )

• mice begin to die around 100 days of age, with 70% survival at 200-300 days of age

nervous system

increased neuroblastoma incidence ( J:228124 , J:261033 )

• tumors are classified as neuroblastoma, stroma-poor, poorly differentiated or differentiating (J:228124)

• tumor onset occurs later than in mice carrying the Alk^tm2.1Ics allele (J:228124)

• abdominal tumors are median, perivascular and locally invasive without evidence of macroscopic tumor spread to other organs (J:228124)

• tumors at 2 or 3 locations (abdominal/thoracic/cervical) are seen in 70% of mice (J:228124)

• mice treated with vandetanib, a kinase inhibitor, or crizotinib, show a reduction in abdominal tumor weight (J:228124)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:228124 , J:261033

Allelic Composition	Alk^tm1.1Ics/?
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alk^tm1.1Ics mutation (0 available); any Alk mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal stellate ganglion morphology ( J:228124 )

• enlargement of the stellate ganglia

enlarged superior cervical ganglion ( J:228124 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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