Phenotypes associated with this allele

• Allele Symbol: Brpf1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5705128
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brpf1^tm1b(EUCOMM)Wtsi/Brpf1^tm1b(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5896564

Genotype
MGI:5896564

hm1

• Allelic Composition: Brpf1^{tm1b(EUCOMM)Wtsi}/Brpf1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0069_1_G06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:222304 )

• although recovered at normal Mendelian ratios at E8.75, homozygotes die around E9.5; no viable homozygotes are obtained at or after E11.5

embryo

embryonic growth arrest ( J:222304 )

• embryonic development does not progress properly after E9.5

abnormal embryo morphology ( J:222304 )

• most homozygous embryos exhibit severe abnormalities at E9.5