Phenotypes associated with this allele

• Allele Symbol: Trit1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5704516
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trit1^tm1.1(KOMP)Vlcg/Trit1^tm1.1(KOMP)Vlcg	B6N(Cg)-Trit1^tm1.1(KOMP)Vlcg/J	MGI:6376184
hm2	Trit1^tm1.1(KOMP)Vlcg/Trit1^tm1.1(KOMP)Vlcg	C57BL/6N-Trit1^tm1.1(KOMP)Vlcg/J	MGI:6263776
ht3	Trit1^tm1.1(KOMP)Vlcg/Trit1^+	C57BL/6N-Trit1^tm1.1(KOMP)Vlcg/J	MGI:6263775

Genotype
MGI:6376184

hm1

• Allelic Composition: Trit1^{tm1.1(KOMP)Vlcg}/Trit1^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Trit1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13142A-H7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although normal blastocysts are present at expected Mendelian ratios at E3.5, no homozygous embryos are recovered at E7.5

• however, blastocysts hatch from the zona pellucida and form fairly normal outgrowth colonies after 3 days in culture

Genotype
MGI:6263776

hm2

• Allelic Composition: Trit1^{tm1.1(KOMP)Vlcg}/Trit1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Trit1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13142A-H7

Data Sources

IMPC Data for Trit1

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6263775

ht3

• Allelic Composition: Trit1^{tm1.1(KOMP)Vlcg}/Trit1⁺
• Genetic Background: C57BL/6N-Trit1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13142A-H7

Data Sources

IMPC Data for Trit1

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - JAX