All Phenotypes Gabrb1<m2Qnma> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gabrb1^m2Qnma
mutation 2, Quentin M Anstee
MGI:5704359

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gabrb1^m2Qnma/Gabrb1⁺	involves: BALB/cAnN * C3H/HeH	MGI:5704368

Allelic Composition	Gabrb1^m2Qnma/Gabrb1⁺
Genetic Background	involves: BALB/cAnN * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrb1^m2Qnma mutation (0 available); any Gabrb1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal corpus luteum morphology ( J:223500 )

• underdeveloped

female infertility ( J:223500 )

homeostasis/metabolism

decreased growth hormone level ( J:223500 )

• in the pituitary

decreased prolactin level ( J:223500 )

• in the pituitary

behavior/neurological

alcohol preference ( J:223500 )

nervous system

abnormal single cell response ( J:223500 )

• nucleus accumbens medium spiny neurons exhibit enhanced tonic conductance compared with wild-type cells

abnormal miniature inhibitory postsynaptic currents ( J:223500 )

• nucleus accumbens medium spiny neurons exhibit reduced miniature inhibitory postsynaptic currents frequency and prolonged decay time compared to in wild-type cells

growth/size/body

decreased body size ( J:223500 )

• not as pronounced as in Gabrb1^m1Qnma heterozygotes

endocrine/exocrine glands

abnormal corpus luteum morphology ( J:223500 )

• underdeveloped

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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