Phenotypes associated with this allele

• Allele Symbol: Del(4Cyp2j13-Cyp2j5)1Brs
• Allele Name: deletion, Chr 4, Brian Seed 1
• Allele ID: MGI:5704342
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(4Cyp2j13-Cyp2j5)1Brs/Del(4Cyp2j13-Cyp2j5)1Brs	involves: C57BL/6	MGI:5707194
cx2	Del(4Cyp2j13-Cyp2j5)1Brs/Del(4Cyp2j13-Cyp2j5)1Brs Tg(CYP2J2)#Brs/?	involves: C57BL/6	MGI:5707195

Genotype
MGI:5707194

hm1

• Allelic Composition: Del(4Cyp2j13-Cyp2j5)1Brs/Del(4Cyp2j13-Cyp2j5)1Brs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:223128 )

N • blood pressure and heart rate are normal

N • normal cardiac output and systemic vascular resistance

N • left ventricular systolic and diastolic functions are normal

abnormal pulmonary vascular resistance ( J:223128 )

• left mainstem bronchial occlusion does not result in the expected increase of left pulmonary resistance

abnormal vasoconstriction ( J:223128 )

• absence of hypoxic pulmonary vasoconstriction due to left mainstem bronchial occlusion

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:223128 )

N • normal arterial blood pH and carbon dioxide partial pressure

abnormal oxygen level ( J:223128 )

• decreased arterial partial pressure relative to controls after left mainstem bronchial occlusion

muscle

abnormal vasoconstriction ( J:223128 )

• absence of hypoxic pulmonary vasoconstriction due to left mainstem bronchial occlusion

Genotype
MGI:5707195

cx2

• Allelic Composition: Del(4Cyp2j13-Cyp2j5)1Brs/Del(4Cyp2j13-Cyp2j5)1Brs; Tg(CYP2J2)#Brs/?
• Genetic Background: involves: C57BL/6

cardiovascular system

cardiovascular system phenotype ( J:223128 )

N • normal expected increase of left pulmonary vascular resistance as a result of left mainstem bronchial occlusion

N • hypoxic pulmonary vasoconstriction due to left mainstem bronchial occlusion as expected

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:223128 )

N • decrease in arterial partial pressure after left mainstem bronchial occlusion is comparable to controls