Phenotypes associated with this allele

• Allele Symbol: Adgrg3^tm1Zgwg
• Allele Name: targeted mutation 1, Zhugang Wang
• Allele ID: MGI:5704321
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgrg3^tm1Zgwg/Adgrg3^tm1Zgwg	involves: 129 * C57BL/6	MGI:5707053

Genotype
MGI:5707053

hm1

• Allelic Composition: Adgrg3^tm1Zgwg/Adgrg3^tm1Zgwg
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:222670 )

N • spleen germinal center development is normal

abnormal immune system morphology ( J:222670 )

abnormal B cell morphology ( J:222670 )

decreased transitional stage T1 B cell number ( J:222670 )

increased transitional stage T2 B cell number ( J:222670 )

• proportionally increased but not in absolute numbers

decreased mature B cell number ( J:222670 )

• B220⁺ cell population is reduced in bone marrow, spleen, and peripheral blood

decreased follicular B cell number ( J:222670 )

• significantly reduced in number

abnormal spleen morphology ( J:222670 )

abnormal spleen B cell follicle morphology ( J:222670 )

• lack discrete perifollicular marginal zone

abnormal spleen B cell follicle shape ( J:222670 )

• diffuse and irregular follicular areas

abnormal spleen marginal zone morphology ( J:222670 )

• marginal zone area is larger than in controls

increased marginal zone B cell number ( J:222670 )

• significantly increased

abnormal immune system physiology ( J:222670 )

increased B cell apoptosis ( J:222670 )

abnormal immunoglobulin level ( J:222670 )

decreased IgA level ( J:222670 )

• significantly decreased at 3 months

abnormal IgG level ( J:222670 )

abnormal IgG1 level ( J:222670 )

decreased IgG1 level ( J:222670 )

• significantly decreased at 3 months

increased IgG1 level ( J:222670 )

• levels are higher in response to T dependent antigen

abnormal IgG2 level ( J:222670 )

increased IgG2a level ( J:222670 )

• significantly increased at 3 months

decreased IgG2b level ( J:222670 )

• significantly decreased at 3 months

decreased IgG3 level ( J:222670 )

• lower levels in response to T independent antigens

decreased IgM level ( J:222670 )

• lower levels in response to both T independent and T dependent antigens

hematopoietic system

increased B cell apoptosis ( J:222670 )

abnormal B cell morphology ( J:222670 )

decreased transitional stage T1 B cell number ( J:222670 )

increased transitional stage T2 B cell number ( J:222670 )

• proportionally increased but not in absolute numbers

decreased mature B cell number ( J:222670 )

• B220⁺ cell population is reduced in bone marrow, spleen, and peripheral blood

decreased follicular B cell number ( J:222670 )

• significantly reduced in number

abnormal spleen morphology ( J:222670 )

abnormal spleen B cell follicle morphology ( J:222670 )

• lack discrete perifollicular marginal zone

abnormal spleen B cell follicle shape ( J:222670 )

• diffuse and irregular follicular areas

abnormal spleen marginal zone morphology ( J:222670 )

• marginal zone area is larger than in controls

increased marginal zone B cell number ( J:222670 )

• significantly increased

abnormal immunoglobulin level ( J:222670 )

decreased IgA level ( J:222670 )

• significantly decreased at 3 months

abnormal IgG level ( J:222670 )

abnormal IgG1 level ( J:222670 )

decreased IgG1 level ( J:222670 )

• significantly decreased at 3 months

increased IgG1 level ( J:222670 )

• levels are higher in response to T dependent antigen

abnormal IgG2 level ( J:222670 )

increased IgG2a level ( J:222670 )

• significantly increased at 3 months

decreased IgG2b level ( J:222670 )

• significantly decreased at 3 months

decreased IgG3 level ( J:222670 )

• lower levels in response to T independent antigens

decreased IgM level ( J:222670 )

• lower levels in response to both T independent and T dependent antigens

cellular

increased B cell apoptosis ( J:222670 )