Analysis Tools
behavior/neurological
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• some mice exhibit spontaneous recurrent temporal lobe seizures
• however, adult mice do not exhibit overt abnormalities in the brain
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• mice exhibit enhanced sensitivity to stimulus-evoked seizures in the kindling model, with the initial stimulation evoking longer electrographic seizures accompanied by behavioral seizures and subsequent stimulations evoking seizures of greater duration and behavioral intensity and fewer stimulations that are required to induce completion of kindling, indicating enhanced susceptibility to epilepsy
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• mice exhibit age-dependent sensitivity to hyperthermia-induced seizures, with 82% of mice at P15 developing seizures when body temperatures are elevated to 42-42.5 degrees Celsius, however, mice at P30 and P60 do not exhibit this sensitivity
• seizures consist of clonic forelimb jerking of abrupt onset and termination, typically lasting more than 40 seconds
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nervous system
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• some mice exhibit spontaneous recurrent temporal lobe seizures
• however, adult mice do not exhibit overt abnormalities in the brain
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• mice exhibit enhanced sensitivity to stimulus-evoked seizures in the kindling model, with the initial stimulation evoking longer electrographic seizures accompanied by behavioral seizures and subsequent stimulations evoking seizures of greater duration and behavioral intensity and fewer stimulations that are required to induce completion of kindling, indicating enhanced susceptibility to epilepsy
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• mice exhibit age-dependent sensitivity to hyperthermia-induced seizures, with 82% of mice at P15 developing seizures when body temperatures are elevated to 42-42.5 degrees Celsius, however, mice at P30 and P60 do not exhibit this sensitivity
• seizures consist of clonic forelimb jerking of abrupt onset and termination, typically lasting more than 40 seconds
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• CA1 pyramidal cells receive reduced inhibitory synaptic input and increased excitatory input
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• CA1 pyramidal neurons show an increase in the frequency of spontaneous EPSCs
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• CA1 pyramidal neurons show a reduction in the frequency of IPSCs
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• CA1 pyramidal neurons show a reduction in amplitude of mIPSCs but not frequency
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