Analysis Tools
skeleton
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• accelerated osteoblast-to-osteocyte transition in the femur
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• enlarged skull at 11 weeks of age
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• enlarged limb bones at 11 weeks of age
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• enlarged lower limb bones at 11 weeks of age
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long femur
(
J:226604
)
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• enlarged fibulae at 11 weeks of age
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• enlarged tibiae at 11 weeks of age
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• enlarged metatarsals at 11 weeks of age
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• enlarged scapula at 11 weeks of age
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• enlarged ribs at 11 weeks of age
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• enlarged spine at 11 weeks of age
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• increased DMP-1 (osteocyte marker) levels in femur, indicating an increase in bone mineral deposition and an acceleration of osteoblast-to-osteocyte transition
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• average whole-body BMDs are increased by 8.9% at 11 weeks of age
• however, no severe gross developmental anomalies are observed
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• average femoral BMDs are increased by 20% at 11 weeks of age
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• significantly increased cortical bone thickness of tibiae and fibulae at 11 weeks of age
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• increased number and length of osteocyte dendrites in the femur
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• number of femoral trabecular bones shows a tendency to increase
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• significantly decreased separations between femoral trabecular bones
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• bone formation rate by osteoblasts is accelerated in the femur
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limbs/digits/tail
macrodactyly
(
J:226604
)
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• enlarged digits at 11 weeks of age
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• enlarged limb bones at 11 weeks of age
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• enlarged lower limb bones at 11 weeks of age
|
long femur
(
J:226604
)
|
• enlarged fibulae at 11 weeks of age
|
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• enlarged tibiae at 11 weeks of age
|
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• enlarged metatarsals at 11 weeks of age
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craniofacial
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• enlarged skull at 11 weeks of age
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cellular
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• accelerated osteoblast-to-osteocyte transition in the femur
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