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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp63m1Mhda
mutation 1, Martin Hrabe de Angelis
MGI:5702898
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp63m1Mhda/Trp63m1Mhda C3HeB/FeJ-Trp63m1Mhda MGI:5702915
ht2
 		Trp63m1Mhda/Trp63+ C3HeB/FeJ-Trp63m1Mhda MGI:5702913


Genotype
MGI:5702915
hm1
Allelic
Composition		 Trp63m1Mhda/Trp63m1Mhda
Genetic
Background		 C3HeB/FeJ-Trp63m1Mhda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63m1Mhda mutation (1 available); any Trp63 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial morphology ( J:82809 )
• "Darth Vader-like" appearance observed at embryonic day (E) 15

limbs/digits/tail

mortality/aging




Genotype
MGI:5702913
ht2
Allelic
Composition		 Trp63m1Mhda/Trp63+
Genetic
Background		 C3HeB/FeJ-Trp63m1Mhda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63m1Mhda mutation (1 available); any Trp63 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:82809 )
• mice heterozygous for this mutation are viable and exhibit no obvious abnormality




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory