Phenotypes associated with this allele

• Allele Symbol: Orai1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5700370
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orai1^tm1b(EUCOMM)Hmgu/Orai1^tm1b(EUCOMM)Hmgu	C57BL/6N-Orai1^tm1b(EUCOMM)Hmgu/Bay	MGI:6263075
ht2	Orai1^tm1b(EUCOMM)Hmgu/Orai1^+	C57BL/6N-Orai1^tm1b(EUCOMM)Hmgu/Bay	MGI:6263074

Genotype
MGI:6263075

hm1

• Allelic Composition: Orai1^{tm1b(EUCOMM)Hmgu}/Orai1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Orai1^{tm1b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0538_6_C03

Data Sources

IMPC Data for Orai1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

embryo

abnormal embryo size ( J:211773 )

IMPC - BCM

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - BCM

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:6263074

ht2

• Allelic Composition: Orai1^{tm1b(EUCOMM)Hmgu}/Orai1⁺
• Genetic Background: C57BL/6N-Orai1^{tm1b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0538_6_C03

Data Sources

IMPC Data for Orai1

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

cardiovascular system

abnormal sinus arrhythmia ( J:211773 )

IMPC - BCM