All Phenotypes Cidec<tm1.1Gonz> MGI Mouse

hepatic steatosis ( J:226899 )

• liver is enlarged and yellowish liver in mice fed high fat diet as compared to HFD-fed controls

• liver has moderate to severe macrovesicular/microvesicular steatosis around central veins

increased brown adipose tissue amount ( J:226899 )

• increase in interscapular brown adipose tissue as a percentage of body weight in mice fed high fat diet (HFD) for 17 weeks as compared to HFD-fed controls

• however, weight is similar to controls after 30 weeks of treatment

decreased percent body fat/body weight ( J:226899 )

• decreased fat mass as a percentage of body weight in chow fed mice is observed at 28 weeks of age

• decrease in fat mass as percentage of body weight in mice fed high fat diet (HFD) for 17 weeks as compared to HFD-fed controls

abnormal white adipose tissue morphology ( J:226899 )

• color of epididymal white adipose tissue is slightly darker than controls in both chow diet and high fat diet

decreased white adipose tissue amount ( J:226899 )

• decreased epididymal white adipose tissue (eWAT) weight as a percentage of body weight is observed at 28 weeks of age in chow fed mice

• no differences in brown adipose tissue (BAT) weight are observed on chow diet

• decrease in WAT as percentage of body weight in mice fed high fat diet (HFD) for 17 weeks as compared to HFD-fed controls

• decrease is observed in epididymal, inguinal, retroperitoneal, perirenal WAT and mesentery

abnormal white fat cell morphology ( J:226899 )

• 76% of adipocytes found in white adipose tissue are small with multiocular lipid droplets

• 79% of adipocytes found in epididymal white adipose tissue in mice fed high fat diet are small with multiocular lipid droplets

• 85% of adipocytes found in mesentery in mice fed high fat diet are small with multiocular lipid droplets

• remaining adipocytes are normal sized with unilocular lipid droplets in mice fed chow diet or high fat diets

decreased white fat cell size ( J:226899 )

increased adipocyte glucose uptake ( J:226899 )

• glucose uptake in WAT from mice on high fat diet is increased, but rate is similar to controls in skeletal muscle and BAT

abnormal white adipose tissue physiology ( J:226899 )

hyperactivity ( J:226899 )

• activity is increased following 8 weeks of high fat feeding as compared to controls

increased lean body mass ( J:226899 )

• increased lean mass as a percentage of body weight is observed at 28 weeks of age

decreased susceptibility to diet-induced obesity ( J:226899 )

• male and female mice gain less weight on high fat (HFD) diet as compared to HFD-fed controls

• weight increase plateaus after 8 weeks of high fat diet

• decrease in fat mass after 17 weeks on HFD at as compared to HFD-fed controls

abnormal adaptive thermogenesis ( J:226899 )

• thermogenic capacity is increased following administration of a beta3-adrenergic agonist in mice fed high fat diet as compared to like-treated controls

increased circulating insulin level ( J:226899 )

• hyperinsulinemia is observed in mice fed high fat diet for 14 weeks as compared to controls

abnormal circulating lipid level ( J:226899 )

• dsylipidemia

• basal lipolytic activities are increased in adipocytes in mice on high fat diet

increased circulating free fatty acids level ( J:226899 )

• increased concentrations of non-essential fatty acids are found in mice fed high fat diet as compared to HFD-fed controls

increased circulating triglyceride level ( J:226899 )

• increased serum triglyceride levels are found in mice fed high fat diet as compared to HFD-fed controls

increased circulating alanine transaminase level ( J:226899 )

• elevated serum alanine aminotransferase levels are found in mice fed high fat diet as compared to HFD-fed controls

increased energy expenditure ( J:226899 )

• total energy expenditure is increased by 12% in last 6 weeks of 8 week high fat feeding as compared to controls

decreased susceptibility to diet-induced obesity ( J:226899 )

• male and female mice gain less weight on high fat (HFD) diet as compared to HFD-fed controls

• weight increase plateaus after 8 weeks of high fat diet

• decrease in fat mass after 17 weeks on HFD at as compared to HFD-fed controls

increased oxygen consumption ( J:226899 )

• resting oxygen consumption is increased following 8 weeks of high fat feeding as compared to controls

• total whole body oxygen consumption is increased following 8 weeks of high fat feeding as compared to controls

decreased respiratory quotient ( J:226899 )

• RER is decreased following 8 weeks of high fat feeding as compared to controls

insulin resistance ( J:226899 )

• decreased insulin sensitivity in male and female mice fed high fat diet for 13 weeks as compared to controls

• other observations include: increased HOMA index, decreased glucose infusion rate in hyperinsulinemic-euglycemic clamp study, decreased whole body glycolysis rate, but an unchanged rate of glucose disappearance

increased adipocyte glucose uptake ( J:226899 )

• glucose uptake in WAT from mice on high fat diet is increased, but rate is similar to controls in skeletal muscle and BAT

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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