About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lhx1tm2.1Rob
targeted mutation 2.1, Elizabeth J Robertson
MGI:5698528
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lhx1tm1Bhr/Lhx1tm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA MGI:5699420


Genotype
MGI:5699420
cn1
Allelic
Composition		 Lhx1tm1Bhr/Lhx1tm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Lhx1tm1Bhr mutation (2 available); any Lhx1 mutation (22 available)
Lhx1tm2.1Rob mutation (0 available); any Lhx1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:226614 )
• by E9.5, mice exhibit cardiac defects including abnormal looping, expanded pericardium and cardia bifida compared with wild-type mice
enlarged pericardium ( J:226614 )
• expanded pericardium

embryo
abnormal endoderm development ( J:226614 )
• reduced anterior endoderm
abnormal primitive node morphology ( J:226614 )
• thickened distal tip with a local out-pocketing of cells on the surface of the distal tip

nervous system
abnormal nervous system development ( J:226614 )
• reduced neural tissue

cellular
cellular necrosis ( J:226614 )
• necrotic embryos by E10.5

growth/size/body
embryonic growth retardation ( J:226614 )
• by E10.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory