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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lhx1tm2.1Rob
targeted mutation 2.1, Elizabeth J Robertson
MGI:5698528
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lhx1tm1Bhr/Lhx1tm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA MGI:5699420


Genotype
MGI:5699420
cn1
Allelic
Composition		 Lhx1tm1Bhr/Lhx1tm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Lhx1tm1Bhr mutation (2 available); any Lhx1 mutation (21 available)
Lhx1tm2.1Rob mutation (0 available); any Lhx1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:226614 )
• by E9.5, mice exhibit cardiac defects including abnormal looping, expanded pericardium and cardia bifida compared with wild-type mice
enlarged pericardium ( J:226614 )
• expanded pericardium

embryo
abnormal endoderm development ( J:226614 )
• reduced anterior endoderm
abnormal primitive node morphology ( J:226614 )
• thickened distal tip with a local out-pocketing of cells on the surface of the distal tip

nervous system
abnormal nervous system development ( J:226614 )
• reduced neural tissue

cellular
cellular necrosis ( J:226614 )
• necrotic embryos by E10.5

growth/size/body
embryonic growth retardation ( J:226614 )
• by E10.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory