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Allele Symbol Allele Name Allele ID |
Dbx1tm2Jcor targeted mutation 2, Joshua Corbin MGI:5696633 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• attenuated response to predator (rat) odor is observed in females ( as measured by corticosterone levels in the lateral hypothalamus area) as compared to control females
• males (either control or mutant) do not exhibit a response
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• slices from the lateral hypothalamic area (LH) exhibit 85% lower spike density in low glucose
• slices from the lateral hypothalamic area (LH) exhibit 50% lower average spike frequency in high glucose
• however, glucose tolerance is not affected
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• females exhibit a similar response following presentation with either rat or benign odor in contrast to controls
• females exhibit fewer and shorter escape behaviors as compared to controls following presentation with rat odor
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• females eat less than controls on a restricted diet
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• decrease in amount of food consumed following a 12 hour fast is observed in females, but not males
• however, daily food consumption is similar to controls
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• activity, as determined by horizontal line crossings, is increased in males, but not in females
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• decreased body weight in males, but not females, is observed after weaning
• females exhibit a decrease in body weight under restricted or high fat diets
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• males exhibit decrease in body fat composition after 7 weeks on high fat diet
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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