Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mki67em1Dfis mutation
(0 available);
any
Mki67 mutation
(147 available)
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neoplasm
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• 16 weeks after AOM-DSS treatment, homozygotes exhibit no macroscopic intestinal neoplastic lesions, unlike similarly treated wild-type and heterozygous mice
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homeostasis/metabolism
immune system
N |
• during induction of colon tumors by azoxymethane/dextran sodium sulfate (AOM-DSS) treatment, DSS-treated homozygotes show a similar decrease in body weight and a typical DSS-induced colitis (with increased numbers of immune cells in the lamina propria, moderate crypt cells damage, and hyperplasia) relative to heterozygous controls
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Allelic Composition |
Mki67em1Dfis/Mki67+
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Genetic Background |
involves: C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mki67em1Dfis mutation
(0 available);
any
Mki67 mutation
(147 available)
|
|
|
neoplasm
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• 16 weeks after induction of colon tumors by azoxymethane/dextran sodium sulfate (AOM-DSS) treatment, heterozygotes show a significant increase in total lesion area (mm2) but no difference in the total number of lesions/mouse relative to similarly treated wild-type controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation
(0 available);
any
Apc mutation
(154 available)
Mki67em1Dfis mutation
(0 available);
any
Mki67 mutation
(147 available)
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neoplasm
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• 6 months after induction of colon tumors by AOM-DSS treatment, mice exhibit a significant decrease both in the number of neoplastic lesions/mouse and in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67em1Dfis and Apctm1Cip
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• 6 months after AOM-DSS treatment, mice exhibit a significant decrease in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67em1Dfis and Apctm1Cip
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homeostasis/metabolism