Phenotypes associated with this allele

• Allele Symbol: St3gal4^tm1.1Bsi
• Allele Name: targeted mutation 1.1, RIKEN Brain Science Institute
• Allele ID: MGI:5695539
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	St3gal4^tm1.1Bsi/St3gal4^tm1.1Bsi	B6J.B6N-St3gal4^tm1.1Bsi	MGI:5811794

Genotype
MGI:5811794

hm1

• Allelic Composition: St3gal4^tm1.1Bsi/St3gal4^tm1.1Bsi
• Genetic Background: B6J.B6N-St3gal4^tm1.1Bsi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased kindling response ( J:217104 )

♂ • following repeated amygdala-kindling stimulation (once a day for 18 days), mice show a significant reduction in the number of afterdischarge spikes, duration of the afterdischarge period, freezing times, and transition among stages of seizure severity relative to wild-type controls on days 15-18; differences are most obvious on day 18

♂ • on day 18, only 17% of mice exhibit tonic-clonic seizures versus 100% of wild-type controls, indicating protection against temporal lobe epilepsy

behavior/neurological

abnormal conditioned emotional response ( J:217104 )

♂ • in delay fear conditioning tests, mice show enhanced freezing during the auditory tone test, with a 2.2-fold increase in mean duration of freezing (%) for the 30-s period between 90 and 120 s and a 1.9-fold increase in total freezing times (%) relative to wild-type controls

♂ • however, foot shock sensitivity, sensory processing, and freezing behaviors during the initial conditioning or contextual tests are normal

increased coping response ( J:217104 )

♂ • in the tail suspension test, mice show a 1.1-fold decrease in the mean duration of total immobility (%) relative to wild-type controls, indicating decreased suspension despair

behavioral despair ( J:217104 )

♂ • in the forced swim test, mice show a 1.5-fold increase in the mean duration of total immobility (%) relative to wild-type controls, indicating increased swimming despair

increased anxiety-related response ( J:217104 )

♂ • in the open-field test, mice enter the center of the arena less often than wild-type controls and fail to show an increase in the frequency of entry from the first to second trial, indicating poor acclimation to the center area

♂ • however, total distance travelled during the three trials of 5-min test periods is normal

increased fear-related response ( J:217104 )

♂ • mice show enhanced freezing during delay auditory fear conditioning

abnormal sleep pattern ( J:217104 )

♂ • mice fail to show siesta-like sleep between 00:00 and 04:00 hours, unlike wild-type controls

decreased frequency of paradoxical sleep ( J:217104 )

♂ • mice show a 3.6-fold decrease in the mean duration of the REM period (%) relative to wild-type controls

♂ • however, no differences are observed in awake or non-REM sleep periods

decreased kindling response ( J:217104 )

♂ • following repeated amygdala-kindling stimulation (once a day for 18 days), mice show a significant reduction in the number of afterdischarge spikes, duration of the afterdischarge period, freezing times, and transition among stages of seizure severity relative to wild-type controls on days 15-18; differences are most obvious on day 18

♂ • on day 18, only 17% of mice exhibit tonic-clonic seizures versus 100% of wild-type controls, indicating protection against temporal lobe epilepsy

homeostasis/metabolism

abnormal insulin-like growth factor I level ( J:217104 )

♂ • mice show a 2.2-fold reduction of brain Igf1 mRNA levels in the apical part of the cerebral cortex relative to wild-type controls

decreased growth hormone level ( J:217104 )

♂ • mice show a 2.8-fold reduction of brain growth hormone (GH) mRNA levels in the apical part of the cerebral cortex relative to wild-type controls