Phenotypes associated with this allele

• Allele Symbol: Smc6^tm1.1Arln
• Allele Name: targeted mutation 1.1, Alan R Lehmann
• Allele ID: MGI:5695351
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smc6^tm1.1Arln/Smc6^tm1.1Arln	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:5695443

Genotype
MGI:5695443

hm1

• Allelic Composition: Smc6^tm1.1Arln/Smc6^tm1.1Arln
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:220422 )

N • mice are born in normal Mendelian frequencies

homeostasis/metabolism

increased circulating glucose level ( J:220422 )

• mild in ad libitum fed mice

decreased circulating HDL cholesterol level ( J:220422 )

• slight after overnight fasting

increased circulating calcium level ( J:220422 )

• mild in ad libitum fed mice

hematopoietic system

macrocytosis ( J:220422 )

• mild

thrombocytosis ( J:220422 )

• mild to moderate

increased leukocyte cell number ( J:220422 )

• mild to moderate

decreased IgG2b level ( J:220422 )

• slightly

behavior/neurological

abnormal motor coordination/balance ( J:220422 )

• increased tail elevation and decreased pelvic elevation during walking compared with wild-type mice

increased thermal nociceptive threshold ( J:220422 )

• more pronounced in female than male mice

adipose tissue

decreased total body fat amount ( J:220422 )

• slight

growth/size/body

growth/size/body region phenotype ( J:220422 )

N • mice exhibit normal body size and lean body mass

decreased body mass index ( J:220422 )

immune system

increased leukocyte cell number ( J:220422 )

• mild to moderate

decreased IgG2b level ( J:220422 )

• slightly