Phenotypes associated with this allele

• Allele Symbol: Socs2^tm1Vem
• Allele Name: targeted mutation 1, Vicky E MacRae
• Allele ID: MGI:5695065
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Socs2^tm1Vem/Socs2^tm1Vem	involves: 129P2/OlaHsd * C57BL/6J	MGI:5695072

Genotype
MGI:5695072

hm1

• Allelic Composition: Socs2^tm1Vem/Socs2^tm1Vem
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:225936 )

N • mice exhibit normal periosteal and endosteal perimeter, eccentricity, bone mineral density (total and trabecular), and cortical cross-sectional thickness

abnormal tibia morphology ( J:225936 )

• increased mean moment of inertia

increased diameter of tibia ( J:225936 )

long tibia ( J:225936 )

abnormal long bone epiphyseal plate proliferative zone ( J:225936 )

• wider that in wild-type mice

increased width of hypertrophic chondrocyte zone ( J:225936 )

• wider that in wild-type mice

increased long bone epiphyseal plate size ( J:225936 )

• wider that in wild-type mice

increased trabecular bone volume ( J:225936 )

increased compact bone area ( J:225936 )

• increased total cross-sectional bone and total tissue area at the mid-diaphyseal cortical bone

abnormal bone trabecula morphology ( J:225936 )

• trabeculae appear more plate-like and more connected compared to in wild-type mice

increased bone trabecula number ( J:225936 )

decreased bone trabecular spacing ( J:225936 )

increased trabecular bone thickness ( J:225936 )

growth/size/body

increased body weight ( J:225936 )

• at 4 and 7 weeks of age

limbs/digits/tail

abnormal tibia morphology ( J:225936 )

• increased mean moment of inertia

increased diameter of tibia ( J:225936 )

long tibia ( J:225936 )