About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Jak3m3Btlr
mutation 3, Bruce Beutler
MGI:5695010
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Jak3m3Btlr/Jak3m3Btlr C57BL/6J-Jak3m3Btlr MGI:5695044


Genotype
MGI:5695044
hm1
Allelic
Composition		 Jak3m3Btlr/Jak3m3Btlr
Genetic
Background		 C57BL/6J-Jak3m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3m3Btlr mutation (0 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell subpopulation ratio ( J:225935 )
• some mice exhibit an increase in the CD4+ to CD8+ T cell ratio
decreased IgG level ( J:225935 )
• some mice exhibit diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide
impaired humoral immune response ( J:225935 )
• some mice exhibit diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide

hematopoietic system
abnormal T cell subpopulation ratio ( J:225935 )
• some mice exhibit an increase in the CD4+ to CD8+ T cell ratio
decreased IgG level ( J:225935 )
• some mice exhibit diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory