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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Jak3m3Btlr
mutation 3, Bruce Beutler
MGI:5695010
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Jak3m3Btlr/Jak3m3Btlr C57BL/6J-Jak3m3Btlr MGI:5695044


Genotype
MGI:5695044
hm1
Allelic
Composition		 Jak3m3Btlr/Jak3m3Btlr
Genetic
Background		 C57BL/6J-Jak3m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3m3Btlr mutation (0 available); any Jak3 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell subpopulation ratio ( J:225935 )
• some mice exhibit an increase in the CD4+ to CD8+ T cell ratio
decreased IgG level ( J:225935 )
• some mice exhibit diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide
impaired humoral immune response ( J:225935 )
• some mice exhibit diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide

hematopoietic system
abnormal T cell subpopulation ratio ( J:225935 )
• some mice exhibit an increase in the CD4+ to CD8+ T cell ratio
decreased IgG level ( J:225935 )
• some mice exhibit diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory