All Phenotypes Mlkl<m1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mlkl^m1Btlr
mutation 1, Bruce Beutler
MGI:5695009

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlkl^m1Btlr/Mlkl^m1Btlr	C57BL/6J-Mlkl^m1Btlr	MGI:5695047
ht2	Mlkl^m1Btlr/Mlkl⁺	C57BL/6J-Mlkl^m1Btlr	MGI:5695048

Allelic Composition	Mlkl^m1Btlr/Mlkl^m1Btlr
Genetic Background	C57BL/6J-Mlkl^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlkl^m1Btlr mutation (0 available); any Mlkl mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased inflammatory response ( J:225934 )

• mice exhibit resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice

cellular

decreased cell death ( J:225934 )

• mice exhibit resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice

Allelic Composition	Mlkl^m1Btlr/Mlkl⁺
Genetic Background	C57BL/6J-Mlkl^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlkl^m1Btlr mutation (0 available); any Mlkl mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased inflammatory response ( J:225934 )

• mice slight exhibit resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice

cellular

decreased cell death ( J:225934 )

• mice exhibit slight resistance to lipopolysaccharide (LPS)-induced necroptosis compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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