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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasgrp1tm1.1Wz
targeted mutation 1.1, Weiguo Zhang
MGI:5694744
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz B6.Cg-Rasgrp1tm1.1Wz MGI:5695366
cx2
 		Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Tg(TcraTcrb)425Cbn/? 		involves: C57BL/6 * BALB/c MGI:5695369
cx3
 		Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Tg(TcraH-Y,TcrbH-Y)71Vbo/? 		involves: C57BL/6J * DBA/2J MGI:5695367


Genotype
MGI:5695366
hm1
Allelic
Composition		 Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic
Background		 B6.Cg-Rasgrp1tm1.1Wz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1tm1.1Wz mutation (0 available); any Rasgrp1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:225109 )
N
• total thymic cellularity is unaffected
abnormal CD4-positive T cell differentiation ( J:225109 )
• CD4 thymocytes reduced by 4.6% rather than 8.7%
abnormal CD8-positive, alpha-beta T cell differentiation ( J:225109 )
• moderate reduction of CD8+ thymocytes, by 1.3% as compared to 2.4%
increased CD4-positive, alpha-beta memory T cell number ( J:225109 )
• increased number of CD4+ cells with an activated memory phenotype
decreased single-positive T cell number ( J:225109 )
• peripheral CD4+ and CD8+ numbers are reduced modestly in younger mice
increased single-positive T cell number ( J:225109 )
• significantly increased numbers of CD4+ cells by 6 months of age
• CD4+ numbers are preferentially expanded relative to CD8+ cells
enlarged spleen ( J:225109 )
• beginning at about 3-4 months of age
increased spleen weight ( J:225109 )
• greatly increased spleen weights at 6 months of age
decreased T cell proliferation ( J:225109 )
• slight impairment after stimulation
• impairment greater for CD4+ than for CD8+

hematopoietic system
decreased T cell proliferation ( J:225109 )
• slight impairment after stimulation
• impairment greater for CD4+ than for CD8+
enlarged spleen ( J:225109 )
• beginning at about 3-4 months of age
increased spleen weight ( J:225109 )
• greatly increased spleen weights at 6 months of age
abnormal CD4-positive T cell differentiation ( J:225109 )
• CD4 thymocytes reduced by 4.6% rather than 8.7%
abnormal CD8-positive, alpha-beta T cell differentiation ( J:225109 )
• moderate reduction of CD8+ thymocytes, by 1.3% as compared to 2.4%
increased CD4-positive, alpha-beta memory T cell number ( J:225109 )
• increased number of CD4+ cells with an activated memory phenotype
decreased single-positive T cell number ( J:225109 )
• peripheral CD4+ and CD8+ numbers are reduced modestly in younger mice
increased single-positive T cell number ( J:225109 )
• significantly increased numbers of CD4+ cells by 6 months of age
• CD4+ numbers are preferentially expanded relative to CD8+ cells

cellular
decreased T cell proliferation ( J:225109 )
• slight impairment after stimulation
• impairment greater for CD4+ than for CD8+

growth/size/body
enlarged spleen ( J:225109 )
• beginning at about 3-4 months of age
increased spleen weight ( J:225109 )
• greatly increased spleen weights at 6 months of age




Genotype
MGI:5695369
cx2
Allelic
Composition		 Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: C57BL/6 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1tm1.1Wz mutation (0 available); any Rasgrp1 mutation (55 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:225109 )
• only 2% CD4+ thymocytes compared to 26% in heterozygous controls

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:225109 )
• only 2% CD4+ thymocytes compared to 26% in heterozygous controls




Genotype
MGI:5695367
cx3
Allelic
Composition		 Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1tm1.1Wz mutation (0 available); any Rasgrp1 mutation (55 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-positive T cell number ( J:225109 )
• significantly elevated in males but normal CD8+ numbers
decreased single-positive T cell number ( J:225109 )
• reduced CD8+ numbers in females

hematopoietic system
increased double-positive T cell number ( J:225109 )
• significantly elevated in males but normal CD8+ numbers
decreased single-positive T cell number ( J:225109 )
• reduced CD8+ numbers in females




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory