Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rec8tm1b(KOMP)Wtsi mutation
(1 available);
any
Rec8 mutation
(25 available)
|
|
|
reproductive system
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• reduced number (80% of WT) of recombination hotspots in leptotene-like spermatocytes
|
cellular
|
• reduced number (80% of WT) of recombination hotspots in leptotene-like spermatocytes
|
|
• reduced number of double-strand DNA breaks (77% of WT) in spermatocytes
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rec8tm1b(KOMP)Wtsi mutation
(1 available);
any
Rec8 mutation
(25 available)
|
|
Data Sources
|
adipose tissue
hematopoietic system
|
IMPC - JAX
|
homeostasis/metabolism
reproductive system
|
IMPC - JAX
|
cellular
|
• reduced number of double-strand DNA breaks (60-80% of WT or single KO) in spermatocytes
|
homeostasis/metabolism
cellular
|
• reduced number of double-strand DNA breaks (20-30% of WT or single KO) in spermatocytes
|
homeostasis/metabolism
reproductive system
|
• reduced number (25% of WT, 42-61% of either single KO) of recombination hotspots in leptotene-like spermatocytes
|
|
• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes
|
cellular
|
• reduced number (25% of WT, 42-61% of either single KO) of recombination hotspots in leptotene-like spermatocytes
|
|
• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes
|
|
• reduced number of double-strand DNA breaks (40% of either single KO or 60% of WT) in spermatocytes
|
homeostasis/metabolism