All Phenotypes Gsdma3<Mhdaclp1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gsdma3^Mhdaclp1
Martin Hrabe de Angelis clinical phenotype 1
MGI:5694663

Summary

2 genotypes

Allelic Composition	Gsdma3^Mhdaclp1/Gsdma3^Mhdaclp1
Genetic Background	C3HeB/FeJ-Gsdma3^Mhdaclp1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdma3^Mhdaclp1 mutation (0 available); any Gsdma3 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

alopecia ( J:220424 )

• terminal baldness after the second hair loss cycle at 10 to 12 weeks of age

homeostasis/metabolism

• in female and male mice

Allelic Composition	Gsdma3^Mhdaclp1/Gsdma3⁺
Genetic Background	C3HeB/FeJ-Gsdma3^Mhdaclp1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdma3^Mhdaclp1 mutation (0 available); any Gsdma3 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

absent sebaceous gland ( J:220424 )

• in the tail skin and back skin

alopecia ( J:220424 )

• hair loss begins around 3 weeks of age from the neck and progressing downwards

• almost complete alopecia at 6 weeks

• sparse and loose hair coat reappears 2 weeks later but is lost again with recurring baldness at 12 to 14 weeks of age

homeostasis/metabolism

• in male, but not female, mice

endocrine/exocrine glands

absent sebaceous gland ( J:220424 )

• in the tail skin and back skin

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