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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cimap2Retro
Retro
MGI:5694208
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cimap2Retro/Cimap2Retro involves: C57BL/6J MGI:5694603
ht2
 		Cimap2Retro/Cimap2+ involves: C57BL/6J MGI:5694624


Genotype
MGI:5694603
hm1
Allelic
Composition		 Cimap2Retro/Cimap2Retro
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cimap2Retro mutation (1 available); any Cimap2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased T cell proliferation ( J:223336 )
• increased proliferation of np396+ CD8+ T cells after LCMV C13 infection as compared to wild type

immune system
increased T cell proliferation ( J:223336 )
• increased proliferation of np396+ CD8+ T cells after LCMV C13 infection as compared to wild type
increased CD8-positive, alpha-beta T cell number ( J:223336 )
• 10 fold increase in the number of LCMV-specific np396+ CD8+ T cells following infection with LCMV clone 13 (C13) as compared to controls
increased central memory CD8 positive, alpha-beta T cell number ( J:223336 )
• 4 fold increase in number of LCMV Armstrong-specific central memory T CD8+ cells in spleen 70 days after infection
increased activated T cell number ( J:223336 )
• increase in CD44hi CD4+ and CD8+ T cells following LCMV C13 infection
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:223336 )
• 10 fold increase in secondary cytotoxic T lymphocytes following second dose of LCMV Armstrong as compared to wild type
increased cytotoxic T cell cytolysis ( J:223336 )
• increased specific CTL lysis as compared to wild type following infection with LCMV clone 13
increased interferon-gamma secretion ( J:223336 )
• increased production of interferon gamma following LCMV C13 infection
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:223336 )
• mice die from LCMV C13 infection after 14 days; wild-type mice survive

hematopoietic system
increased T cell proliferation ( J:223336 )
• increased proliferation of np396+ CD8+ T cells after LCMV C13 infection as compared to wild type
increased CD8-positive, alpha-beta T cell number ( J:223336 )
• 10 fold increase in the number of LCMV-specific np396+ CD8+ T cells following infection with LCMV clone 13 (C13) as compared to controls
increased central memory CD8 positive, alpha-beta T cell number ( J:223336 )
• 4 fold increase in number of LCMV Armstrong-specific central memory T CD8+ cells in spleen 70 days after infection
increased activated T cell number ( J:223336 )
• increase in CD44hi CD4+ and CD8+ T cells following LCMV C13 infection
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:223336 )
• 10 fold increase in secondary cytotoxic T lymphocytes following second dose of LCMV Armstrong as compared to wild type
increased cytotoxic T cell cytolysis ( J:223336 )
• increased specific CTL lysis as compared to wild type following infection with LCMV clone 13

mortality/aging
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:223336 )
• mice die from LCMV C13 infection after 14 days; wild-type mice survive

neoplasm
decreased lung tumor incidence ( J:223336 )
• decreased number of lung tumors following challenge with B16 F10 melanoma cells as compared to wild type




Genotype
MGI:5694624
ht2
Allelic
Composition		 Cimap2Retro/Cimap2+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cimap2Retro mutation (1 available); any Cimap2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:223336 )
• increase in the number of LCMV-specific np396+ CD8+ T cells following infection with LCMV clone 13 (C13) as compared to controls
• increase in cell numbers is less than in homozygote
increased cytotoxic T cell cytolysis ( J:223336 )
• increased specific CTL lysis as compared to wild type
• increase in cytolysis is less than in homozygote

immune system
increased CD8-positive, alpha-beta T cell number ( J:223336 )
• increase in the number of LCMV-specific np396+ CD8+ T cells following infection with LCMV clone 13 (C13) as compared to controls
• increase in cell numbers is less than in homozygote
increased cytotoxic T cell cytolysis ( J:223336 )
• increased specific CTL lysis as compared to wild type
• increase in cytolysis is less than in homozygote




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory