Phenotypes associated with this allele

• Allele Symbol: Ednra^tm6(Edn1)Hku
• Allele Name: targeted mutation 6, Hiroki Kurihara
• Allele ID: MGI:5693851
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ednra^tm6(Edn1)Hku/Ednra^+	involves: 129 * C57BL/6 * ICR	MGI:5694437

Genotype
MGI:5694437

ht1

• Allelic Composition: Ednra^tm6(Edn1)Hku/Ednra⁺
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Transformation of maxillary components in Ednra^tm6(Edn1)Hku/Ednra⁺ mice

mortality/aging

perinatal lethality, complete penetrance ( J:224515 )

• perinatal death with severe craniofacial defects

craniofacial

abnormal Meckel's cartilage morphology ( J:224515 )

• ectopic cartillage forms lateral to ectopic dentary

• discontinuous to malleus and incus in some instances

abnormal sphenoid bone morphology ( J:224515 )

• deformation or absence of pterygoid, ala temporalis and lamina obdurans

abnormal temporal bone squamous part morphology ( J:224515 )

• reduced and divided into 3-4 parts

abnormal jaw morphology ( J:224515 )

abnormal mandible morphology ( J:224515 )

• a second set of mandibular components replacing parts of the maxillary

• tip of second dentary is fused to the premaxillary bone

• original mandible relatively normal

abnormal mandibular ramus morphology ( J:224515 )

small mandibular condyloid process ( J:224515 )

• shortened

short mandibular coronoid process ( J:224515 )

• shortened

upper jaw to lower jaw transformation ( J:224515 )

• maxillary components are replaced with a second set of mandibular components

• dentary-like bone carrying an incisor found in the maxillary region

abnormal palatine bone morphology ( J:224515 )

• deformed or absent

abnormal middle ear ossicle morphology ( J:224515 )

abnormal gonial bone morphology ( J:224515 )

• duplicated along with ectotympanic bone

abnormal stapes morphology ( J:224515 )

• deformed and fused to the styloid process

incudomalleolar fusion ( J:224515 )

• malleus and incus are fused

abnormal masseter muscle morphology ( J:224515 )

• new muscle mass connecting normal and ectopic dentaries

• possibly a duplicated masseter

anteriorly rotated ears ( J:224515 )

• anteriorly shifted ears

muscle

abnormal masseter muscle morphology ( J:224515 )

• new muscle mass connecting normal and ectopic dentaries

• possibly a duplicated masseter

nervous system

abnormal mandibular nerve morphology ( J:224515 )

• motor root of the trigeminal innervates both the mandible and the transformed maxilla

integument

absent vibrissae ( J:224515 )

• at E18.5

vision/eye

eyelids open at birth ( J:224515 )

• eyelids are open at E18.5

growth/size/body

abnormal jaw morphology ( J:224515 )

abnormal mandible morphology ( J:224515 )

• a second set of mandibular components replacing parts of the maxillary

• tip of second dentary is fused to the premaxillary bone

• original mandible relatively normal

abnormal mandibular ramus morphology ( J:224515 )

small mandibular condyloid process ( J:224515 )

• shortened

short mandibular coronoid process ( J:224515 )

• shortened

upper jaw to lower jaw transformation ( J:224515 )

• maxillary components are replaced with a second set of mandibular components

• dentary-like bone carrying an incisor found in the maxillary region

abnormal palatine bone morphology ( J:224515 )

• deformed or absent

abnormal masseter muscle morphology ( J:224515 )

• new muscle mass connecting normal and ectopic dentaries

• possibly a duplicated masseter

anteriorly rotated ears ( J:224515 )

• anteriorly shifted ears

hearing/vestibular/ear

abnormal middle ear ossicle morphology ( J:224515 )

abnormal gonial bone morphology ( J:224515 )

• duplicated along with ectotympanic bone

abnormal stapes morphology ( J:224515 )

• deformed and fused to the styloid process

incudomalleolar fusion ( J:224515 )

• malleus and incus are fused

anteriorly rotated ears ( J:224515 )

• anteriorly shifted ears

skeleton

abnormal Meckel's cartilage morphology ( J:224515 )

• ectopic cartillage forms lateral to ectopic dentary

• discontinuous to malleus and incus in some instances

abnormal sphenoid bone morphology ( J:224515 )

• deformation or absence of pterygoid, ala temporalis and lamina obdurans

abnormal temporal bone squamous part morphology ( J:224515 )

• reduced and divided into 3-4 parts

abnormal jaw morphology ( J:224515 )

abnormal mandible morphology ( J:224515 )

• a second set of mandibular components replacing parts of the maxillary

• tip of second dentary is fused to the premaxillary bone

• original mandible relatively normal

abnormal mandibular ramus morphology ( J:224515 )

small mandibular condyloid process ( J:224515 )

• shortened

short mandibular coronoid process ( J:224515 )

• shortened

upper jaw to lower jaw transformation ( J:224515 )

• maxillary components are replaced with a second set of mandibular components

• dentary-like bone carrying an incisor found in the maxillary region

abnormal palatine bone morphology ( J:224515 )

• deformed or absent

abnormal middle ear ossicle morphology ( J:224515 )

abnormal gonial bone morphology ( J:224515 )

• duplicated along with ectotympanic bone

abnormal stapes morphology ( J:224515 )

• deformed and fused to the styloid process

incudomalleolar fusion ( J:224515 )

• malleus and incus are fused