mortality/aging
• perinatal death with severe craniofacial defects
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craniofacial
• ectopic cartillage forms lateral to ectopic dentary
• discontinuous to malleus and incus in some instances
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• deformation or absence of pterygoid, ala temporalis and lamina obdurans
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• reduced and divided into 3-4 parts
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• a second set of mandibular components replacing parts of the maxillary
• tip of second dentary is fused to the premaxillary bone
• original mandible relatively normal
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• shortened
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• shortened
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• maxillary components are replaced with a second set of mandibular components
• dentary-like bone carrying an incisor found in the maxillary region
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• deformed or absent
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• duplicated along with ectotympanic bone
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• deformed and fused to the styloid process
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• malleus and incus are fused
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• new muscle mass connecting normal and ectopic dentaries
• possibly a duplicated masseter
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• anteriorly shifted ears
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muscle
• new muscle mass connecting normal and ectopic dentaries
• possibly a duplicated masseter
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nervous system
• motor root of the trigeminal innervates both the mandible and the transformed maxilla
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integument
• at E18.5
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vision/eye
• eyelids are open at E18.5
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growth/size/body
• new muscle mass connecting normal and ectopic dentaries
• possibly a duplicated masseter
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• anteriorly shifted ears
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hearing/vestibular/ear
• duplicated along with ectotympanic bone
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• deformed and fused to the styloid process
|
• malleus and incus are fused
|
• anteriorly shifted ears
|
skeleton
• ectopic cartillage forms lateral to ectopic dentary
• discontinuous to malleus and incus in some instances
|
• deformation or absence of pterygoid, ala temporalis and lamina obdurans
|
• reduced and divided into 3-4 parts
|
• a second set of mandibular components replacing parts of the maxillary
• tip of second dentary is fused to the premaxillary bone
• original mandible relatively normal
|
• shortened
|
• shortened
|
• maxillary components are replaced with a second set of mandibular components
• dentary-like bone carrying an incisor found in the maxillary region
|
• deformed or absent
|
• duplicated along with ectotympanic bone
|
• deformed and fused to the styloid process
|
• malleus and incus are fused
|