Phenotypes associated with this allele

• Allele Symbol: Sec63^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5692793
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sec63^tm1b(EUCOMM)Hmgu/Sec63^tm1b(EUCOMM)Hmgu	C57BL/6N-Sec63^tm1b(EUCOMM)Hmgu/Bay	MGI:6263449
ht2	Sec63^tm1b(EUCOMM)Hmgu/Sec63^+	C57BL/6N-Sec63^tm1b(EUCOMM)Hmgu/Bay	MGI:6263448

Genotype
MGI:6263449

hm1

• Allelic Composition: Sec63^{tm1b(EUCOMM)Hmgu}/Sec63^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Sec63^{tm1b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0812_7_A03

Data Sources

IMPC Data for Sec63

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - HAR

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - HAR

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:6263448

ht2

• Allelic Composition: Sec63^{tm1b(EUCOMM)Hmgu}/Sec63⁺
• Genetic Background: C57BL/6N-Sec63^{tm1b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0812_7_A03

Data Sources

IMPC Data for Sec63

hematopoietic system

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♀

IMPC - HAR

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - HAR

integument

abnormal vibrissa morphology ( J:211773 )

♂

IMPC - HAR

absent vibrissae ( J:211773 )

♂

IMPC - HAR

skeleton

decreased bone mineral density ( J:211773 )

IMPC - HAR