Phenotypes associated with this allele

• Allele Symbol: Pdzk1^{tm2b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692756
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdzk1^tm2b(EUCOMM)Wtsi/Pdzk1^tm2b(EUCOMM)Wtsi	C57BL/6N-Pdzk1^tm2b(EUCOMM)Wtsi/Wtsi	MGI:5883883
ht2	Pdzk1^tm2b(EUCOMM)Wtsi/Pdzk1^+	C57BL/6N-Pdzk1^tm2b(EUCOMM)Wtsi/Wtsi	MGI:5797704

Genotype
MGI:5883883

hm1

• Allelic Composition: Pdzk1^{tm2b(EUCOMM)Wtsi}/Pdzk1^{tm2b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pdzk1^{tm2b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: BEPD0005_1_D09

Data Sources

IMPC Data for Pdzk1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

double lumen aortic arch ( J:239583 )

DMDD

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

abnormal vitelline vein connection ( J:239583 )

DMDD

symmetric azygos veins ( J:239583 )

DMDD

anomalous pulmonary venous connection ( J:239583 )

DMDD

ostium primum atrial septal defect ( J:239583 )

DMDD

atrioventricular septal defect ( J:239583 )

DMDD

embryo

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal Mullerian duct morphology ( J:239583 )

DMDD

abnormal Wolffian duct morphology ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

abnormal lymphatic vessel morphology ( J:239583 )

DMDD

absent connection between subcutaneous lymph vessels and lymph sac ( J:239583 )

DMDD

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

limbs/digits/tail

polydactyly ( J:239583 )

DMDD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

nervous system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

respiratory system

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

skeleton

fusion of vertebral arches ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

Genotype
MGI:5797704

ht2

• Allelic Composition: Pdzk1^{tm2b(EUCOMM)Wtsi}/Pdzk1⁺
• Genetic Background: C57BL/6N-Pdzk1^{tm2b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: BEPD0005_1_D09

Data Sources

IMPC Data for Pdzk1

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - WTSI

increased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - WTSI

increased circulating LDL cholesterol level ( J:211773 )

♂

IMPC - WTSI