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Allele Symbol Allele Name Allele ID |
Ddrgk1tm1b(EUCOMM)Hmgu targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH MGI:5692746 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice died at E12.5 and all mice are dead by E13.5
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• reduced colony-forming units-granulocyte/macrophage and colony-forming units-granulocyte/erythrocyte/macrophage/megakaryocyte in E11.5 fetal livers
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• in E8.5 yolk sac
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• fewer peripheral circulating erythrocytes at E11.5
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• large number of abnormal multinucleated erythroid cells with some exhibiting cell death
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• impaired with a blocked differentiation of TER1119low into TER119med+high cells
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• extensive in the brain (fourth ventricle at E11.5), liver and other tissues (duodenum lumen at E11.5)
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• most mice died at E12.5 and all mice are dead by E13.5
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• impaired with a blocked differentiation of TER1119low into TER119med+high cells
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• most mice died at E12.5 and all mice are dead by E13.5
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• small and disorganized with reduced cellularity and increased cell death at E11.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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