Phenotypes associated with this allele

• Allele Symbol: Alg14^{tm2b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5692664
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alg14^tm2b(EUCOMM)Hmgu/Alg14^tm2b(EUCOMM)Hmgu	B6N(Cg)-Alg14^tm2b(EUCOMM)Hmgu/Bay	MGI:6378206
hm2	Alg14^tm2b(EUCOMM)Hmgu/Alg14^tm2b(EUCOMM)Hmgu	C57BL/6N-Alg14^tm2b(EUCOMM)Hmgu/Bay	MGI:6261839

Genotype
MGI:6378206

hm1

• Allelic Composition: Alg14^{tm2b(EUCOMM)Hmgu}/Alg14^{tm2b(EUCOMM)Hmgu}
• Genetic Background: B6N(Cg)-Alg14^{tm2b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0817_2_A10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• normal looking blastocysts are present at higher than expected Mendelian ratios at E3.5 (42% versus 25%); no embryos or excess resorption sites are recovered at E7.5

embryo

embryo tissue necrosis ( J:279207 )

• blastocysts appear necrotic after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• blastocysts fail to hatch from the zona pellucida after 3 days in culture

cellular

embryo tissue necrosis ( J:279207 )

• blastocysts appear necrotic after 3 days in culture

Genotype
MGI:6261839

hm2

• Allelic Composition: Alg14^{tm2b(EUCOMM)Hmgu}/Alg14^{tm2b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Alg14^{tm2b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0817_2_A10

Data Sources

IMPC Data for Alg14

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - BCM

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM