Phenotypes associated with this allele

• Allele Symbol: Snx10^{tm1c(EUCOMM)Raba}
• Allele Name: targeted mutation 1c, Ricardo A Battaglino
• Allele ID: MGI:5690197
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctsk^tm1(cre)Ska/Ctsk^+ Snx10^tm1c(EUCOMM)Raba/Snx10^tm1c(EUCOMM)Raba	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5690253

Genotype
MGI:5690253

cn1

• Allelic Composition: Ctsk^tm1(cre)Ska/Ctsk⁺; Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba}
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

3-week-old Ctsk^tm1(cre)Ska/Ctsk^tm1(cre)Ska Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} mice are growth retarded, have a tooth eruption defect, and are osteopetrotic

growth/size/body

failure of tooth eruption ( J:224711 )

postnatal growth retardation ( J:224711 )

• by 3 weeks of age, mice exhibit mild growth retardation

skeleton

failure of tooth eruption ( J:224711 )

abnormal osteoclast physiology ( J:224711 )

• osteoclast precursors cultured in vitro show impaired extracellular acidification capacity, have impaired endocytosis, and only form rudimentary ruffled borders

increased bone mineral density ( J:224711 )

• 9 week old bones show a 30% increase in bone mineral density

decreased bone volume ( J:224711 )

• smaller bone volume/tissue volume ratio

osteopetrosis ( J:224711 )

• long bones exhibit marrow cavities filled with unresorbed bone and presence of mineralized trabeculae within the bone marrow space, however trabeculae are not covered by thick layers of unmineralized osteoid

• however, a moth-eaten bone appearance is not seen, osteoid volume per bone volume is normal, and mice are not rachitic

abnormal epiphyseal plate morphology ( J:224711 )

• growth plate thickness is smaller

craniofacial

failure of tooth eruption ( J:224711 )

hematopoietic system

abnormal osteoclast physiology ( J:224711 )

• osteoclast precursors cultured in vitro show impaired extracellular acidification capacity, have impaired endocytosis, and only form rudimentary ruffled borders

immune system

abnormal osteoclast physiology ( J:224711 )

• osteoclast precursors cultured in vitro show impaired extracellular acidification capacity, have impaired endocytosis, and only form rudimentary ruffled borders

digestive/alimentary system

digestive/alimentary phenotype ( J:224711 )

N • mice show normal gastric pH, serum calcium levels and parathyroid hormone levels