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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx3tm3.1Yg
targeted mutation 3.1, Yoram Groner
MGI:5689489
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Runx3tm3.1Yg/Runx3tm3.1Yg Not Specified MGI:5689492


Genotype
MGI:5689492
hm1
Allelic
Composition		 Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3.1Yg mutation (0 available); any Runx3 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:224290 )
decreased body height ( J:224290 )
• short stature

behavior/neurological
abnormal behavior ( J:224898 )
• mice exhibit all phenotypic features seen in Runx3tm1Yg mice
ataxia ( J:224898 )
• congenital ataxia

limbs/digits/tail

digestive/alimentary system
abnormal digestive system physiology ( J:224898 )
• mice exhibit all phenotypic features seen in Runx3tm1Yg mice
intestinal inflammation ( J:224898 )
• mice spontaneously develop inflammatory bowel disease

hematopoietic system
absent Langerhans cell ( J:224898 )
• lack of skin Langerhans cells

skeleton
decreased compact bone area ( J:224290 )
• reduction in cortical area

immune system
absent Langerhans cell ( J:224898 )
• lack of skin Langerhans cells
abnormal immune system physiology ( J:224898 )
• mice exhibit all phenotypic features seen in Runx3tm1Yg mice
intestinal inflammation ( J:224898 )
• mice spontaneously develop inflammatory bowel disease




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory