About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr3M1Btlr
mutation 1, Bruce Beutler
MGI:5688601
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr3M1Btlr/Tlr3M1Btlr C57BL/6J-Tlr3M1Btlr MGI:5688652
ht2
 		Tlr3M1Btlr/Tlr3+ C57BL/6J-Tlr3M1Btlr MGI:5688653


Genotype
MGI:5688652
hm1
Allelic
Composition		 Tlr3M1Btlr/Tlr3M1Btlr
Genetic
Background		 C57BL/6J-Tlr3M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr3M1Btlr mutation (0 available); any Tlr3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:224670 )
• mice exhibit decreased TNFalpha secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
decreased tumor necrosis factor secretion ( J:224670 )
• mice exhibit decreased TNFalpha secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)

hematopoietic system
decreased macrophage cytokine production ( J:224670 )
• mice exhibit decreased TNFalpha secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)




Genotype
MGI:5688653
ht2
Allelic
Composition		 Tlr3M1Btlr/Tlr3+
Genetic
Background		 C57BL/6J-Tlr3M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr3M1Btlr mutation (0 available); any Tlr3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:224670 )
• mice exhibit decreased TNFalpha secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
decreased tumor necrosis factor secretion ( J:224670 )
• mice exhibit decreased TNFalpha secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)

hematopoietic system
decreased macrophage cytokine production ( J:224670 )
• mice exhibit decreased TNFalpha secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory