All Phenotypes Tlr4<Lps-6Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tlr4^Lps-6Btlr
defective lipopolysaccharide response 6 Bruce Beutler
MGI:5688584

Summary

2 genotypes

Allelic Composition	Tlr4^Lps-6Btlr/Tlr4^Lps-6Btlr
Genetic Background	C57BL/6J-Tlr4^Lps-6Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4^Lps-6Btlr mutation (0 available); any Tlr4 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

hematopoietic system

• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

Allelic Composition	Tlr4^Lps-6Btlr/Tlr4⁺
Genetic Background	C57BL/6J-Tlr4^Lps-6Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4^Lps-6Btlr mutation (0 available); any Tlr4 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

hematopoietic system

• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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