All Phenotypes Tlr4<lps-5Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tlr4^lps-5Btlr
defective lipopolysaccharide response 5 Bruce Beutler
MGI:5688583

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr4^lps-5Btlr/Tlr4^lps-5Btlr	C57BL/6J-Tlr4^lps-5Btlr	MGI:5688631

Allelic Composition	Tlr4^lps-5Btlr/Tlr4^lps-5Btlr
Genetic Background	C57BL/6J-Tlr4^lps-5Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4^lps-5Btlr mutation (0 available); any Tlr4 mutation (96 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:224666 )

• reduced B cell frequency

decreased memory B cell number ( J:224666 )

• IgD+ B cells

• IgM+ B cells

• mice are deficient in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

• mice are deficient in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

hematopoietic system

decreased B cell number ( J:224666 )

• reduced B cell frequency

decreased memory B cell number ( J:224666 )

• IgD+ B cells

• IgM+ B cells

• mice are deficient in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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