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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr4lps-4Btlr
defective lipopolysaccharide response 4 Bruce Beutler
MGI:5688512
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr4lps-4Btlr/Tlr4lps-4Btlr C57BL/6J-Tlr4lps-4Btlr MGI:5688566
ht2
 		Tlr4lps-4Btlr/Tlr4+ C57BL/6J-Tlr4lps-4Btlr MGI:5688567


Genotype
MGI:5688566
hm1
Allelic
Composition		 Tlr4lps-4Btlr/Tlr4lps-4Btlr
Genetic
Background		 C57BL/6J-Tlr4lps-4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4lps-4Btlr mutation (0 available); any Tlr4 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage apoptosis ( J:224664 )
• resistance to LPS-induced macrophage necroptosisresistance to LPS-induced macrophage necroptosis
decreased macrophage cytokine production ( J:224664 )
• reduced TNF secretion from macrophages in response to lipolysaccharide (LPS)
decreased tumor necrosis factor secretion ( J:224664 )
• reduced TNF secretion from macrophages in response to lipolysaccharide (LPS)

cellular
decreased macrophage apoptosis ( J:224664 )
• resistance to LPS-induced macrophage necroptosisresistance to LPS-induced macrophage necroptosis

hematopoietic system
decreased macrophage apoptosis ( J:224664 )
• resistance to LPS-induced macrophage necroptosisresistance to LPS-induced macrophage necroptosis
decreased macrophage cytokine production ( J:224664 )
• reduced TNF secretion from macrophages in response to lipolysaccharide (LPS)




Genotype
MGI:5688567
ht2
Allelic
Composition		 Tlr4lps-4Btlr/Tlr4+
Genetic
Background		 C57BL/6J-Tlr4lps-4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4lps-4Btlr mutation (0 available); any Tlr4 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cytokine production ( J:224664 )
• reduced TNF secretion from macrophages in response to lipolysaccharide (LPS)

immune system
decreased macrophage cytokine production ( J:224664 )
• reduced TNF secretion from macrophages in response to lipolysaccharide (LPS)
decreased tumor necrosis factor secretion ( J:224664 )
• educed TNF secretion from macrophages in response to lipolysaccharide (LPS)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory