Phenotypes associated with this allele

• Allele Symbol: Rtcb^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5688394
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rtcb^tm1c(KOMP)Wtsi/Rtcb^tm1c(KOMP)Wtsi Tg(Fcer2a-cre)5Mbu/0	involves: C57BL/6 * CBA * SJL	MGI:5688397

Genotype
MGI:5688397

cn1

• Allelic Composition: Rtcb^{tm1c(KOMP)Wtsi}/Rtcb^{tm1c(KOMP)Wtsi}; Tg(Fcer2a-cre)5Mbu/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell number ( J:216740 )

• slight decrease in the percentage of CD138+ CD22- plasmablasts in cells stimulated with LPS in vitro

abnormal plasma cell morphology ( J:216740 )

• plasmablasts have disorganized and less dense ER structures

abnormal B cell physiology ( J:216740 )

• impaired ability of plasma cells to secrete immunoglobins

decreased IgM level ( J:216740 )

• in culture supernatants of pre-plasmablasts and plasmablasts

• however, the number of plasmablasts secreting IgM is similar to control cultures

hematopoietic system

abnormal B cell number ( J:216740 )

• slight decrease in the percentage of CD138+ CD22- plasmablasts in cells stimulated with LPS in vitro

abnormal plasma cell morphology ( J:216740 )

• plasmablasts have disorganized and less dense ER structures

abnormal B cell physiology ( J:216740 )

• impaired ability of plasma cells to secrete immunoglobins

decreased IgM level ( J:216740 )

• in culture supernatants of pre-plasmablasts and plasmablasts

• however, the number of plasmablasts secreting IgM is similar to control cultures