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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Noc2ltm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:5662104
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Noc2ltm1.1Arte/Noc2ltm1.1Arte
Trp53tm1Brn/Trp53tm1Brn
Tg(CD2-icre)4Kio/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca MGI:5662110
cn2
 		Noc2ltm1.1Arte/Noc2ltm1.1Arte
Tg(CD2-icre)4Kio/0 		involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5662109
cn3
 		Noc2ltm1.1Arte/Noc2ltm1.2Arte
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: FVB/N MGI:5662108


Genotype
MGI:5662110
cn1
Allelic
Composition		 Noc2ltm1.1Arte/Noc2ltm1.1Arte
Trp53tm1Brn/Trp53tm1Brn
Tg(CD2-icre)4Kio/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Noc2ltm1.1Arte mutation (0 available); any Noc2l mutation (19 available)
Tg(CD2-icre)4Kio mutation (4 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:216490 )
N
• rescue of the CD4+CD8+ double positive thymocyte developmental defect
• significant increase in the number of single positive thymocytes in comparison to mutant mice wild-type for Trp53
• significant recovery of DN3L cells close to levels in control mice
• significant increase in the number of late pro-B cells in comparison to mutant mice wild-type for Trp53
decreased pre-B cell number ( J:216490 )
• numbers of pre-B (IgM+B220+CD19+CD43-) are not increased by the absence of Trp53 expression

immune system
decreased pre-B cell number ( J:216490 )
• numbers of pre-B (IgM+B220+CD19+CD43-) are not increased by the absence of Trp53 expression




Genotype
MGI:5662109
cn2
Allelic
Composition		 Noc2ltm1.1Arte/Noc2ltm1.1Arte
Tg(CD2-icre)4Kio/0
Genetic
Background		 involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Noc2ltm1.1Arte mutation (0 available); any Noc2l mutation (19 available)
Tg(CD2-icre)4Kio mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased thymocyte apoptosis ( J:216490 )
• increased apoptosis in DN3 thymocytes
abnormal T cell proliferation ( J:216490 )
• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development
abnormal thymus morphology ( J:216490 )
• lack a distinct cortex-medulla compartmentalization
abnormal thymus cell ratio ( J:216490 )
• approximately 98% of cells recovered from the thymi are double negative
small thymus ( J:216490 )
• at 5-6 weeks of age
thymus hypoplasia ( J:216490 )
• dramatic reduction in cellularity at 5-6 weeks of age
decreased DN3 thymocyte number ( J:216490 )
• decrease in the number of DN3L (larger cycling) cells with a preservation of the DN3E (small, resting G1) population
abnormal thymus involution ( J:216490 )
• severe early involution is seen at 5-6 weeks of age
decreased immature B cell number ( J:216490 )
• dramatic decrease in B220+IgM+ immature B cells in the bone marrow
decreased pro-B cell number ( J:216490 )
• developmental block between very early pro-B cells (B220+CD43+CD19-) and later pro-B (B220+CD43+CD19+) stage
decreased mature B cell number ( J:216490 )
• decrease in B220+IgM+ mature B cells
decreased pre-B cell number ( J:216490 )
• significant decrease in the B220+CD43- pre-B population
decreased double-positive T cell number ( J:216490 )
• almost a complete absence of double positive T cells in the thymus
arrested T cell differentiation ( J:216490 )
• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development
decreased alpha-beta T cell number ( J:216490 )
• decrease in the number of TCR-Beta producing cells
• however, the gamma-delta cell population is preserved
absent T cells ( J:216490 )
• absence of mature splenic T cells at P5
decreased single-positive T cell number ( J:216490 )
• decrease in the number of single positive CD4+ and CD8+ cells
spleen hypoplasia ( J:216490 )
• decrease in T cells and B220+IgM+ mature B cells

endocrine/exocrine glands
increased thymocyte apoptosis ( J:216490 )
• increased apoptosis in DN3 thymocytes
abnormal thymus morphology ( J:216490 )
• lack a distinct cortex-medulla compartmentalization
abnormal thymus cell ratio ( J:216490 )
• approximately 98% of cells recovered from the thymi are double negative
small thymus ( J:216490 )
• at 5-6 weeks of age
thymus hypoplasia ( J:216490 )
• dramatic reduction in cellularity at 5-6 weeks of age
decreased DN3 thymocyte number ( J:216490 )
• decrease in the number of DN3L (larger cycling) cells with a preservation of the DN3E (small, resting G1) population
abnormal thymus involution ( J:216490 )
• severe early involution is seen at 5-6 weeks of age

immune system
increased thymocyte apoptosis ( J:216490 )
• increased apoptosis in DN3 thymocytes
abnormal T cell proliferation ( J:216490 )
• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development
abnormal thymus morphology ( J:216490 )
• lack a distinct cortex-medulla compartmentalization
abnormal thymus cell ratio ( J:216490 )
• approximately 98% of cells recovered from the thymi are double negative
small thymus ( J:216490 )
• at 5-6 weeks of age
thymus hypoplasia ( J:216490 )
• dramatic reduction in cellularity at 5-6 weeks of age
decreased DN3 thymocyte number ( J:216490 )
• decrease in the number of DN3L (larger cycling) cells with a preservation of the DN3E (small, resting G1) population
abnormal thymus involution ( J:216490 )
• severe early involution is seen at 5-6 weeks of age
decreased immature B cell number ( J:216490 )
• dramatic decrease in B220+IgM+ immature B cells in the bone marrow
decreased pro-B cell number ( J:216490 )
• developmental block between very early pro-B cells (B220+CD43+CD19-) and later pro-B (B220+CD43+CD19+) stage
decreased mature B cell number ( J:216490 )
• decrease in B220+IgM+ mature B cells
decreased pre-B cell number ( J:216490 )
• significant decrease in the B220+CD43- pre-B population
decreased double-positive T cell number ( J:216490 )
• almost a complete absence of double positive T cells in the thymus
arrested T cell differentiation ( J:216490 )
• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development
decreased alpha-beta T cell number ( J:216490 )
• decrease in the number of TCR-Beta producing cells
• however, the gamma-delta cell population is preserved
absent T cells ( J:216490 )
• absence of mature splenic T cells at P5
decreased single-positive T cell number ( J:216490 )
• decrease in the number of single positive CD4+ and CD8+ cells
spleen hypoplasia ( J:216490 )
• decrease in T cells and B220+IgM+ mature B cells

cellular
abnormal cell cycle ( J:216490 )
• DN3 thymocytes show a block at the G1/S phase of the cell cycle
increased thymocyte apoptosis ( J:216490 )
• increased apoptosis in DN3 thymocytes
abnormal T cell proliferation ( J:216490 )
• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development




Genotype
MGI:5662108
cn3
Allelic
Composition		 Noc2ltm1.1Arte/Noc2ltm1.2Arte
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Noc2ltm1.1Arte mutation (0 available); any Noc2l mutation (19 available)
Noc2ltm1.2Arte mutation (0 available); any Noc2l mutation (19 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory