Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd6tm1Pche mutation
(0 available);
any
Ankrd6 mutation
(117 available)
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hearing/vestibular/ear
N |
• no hair cell defects are seen in the cochlea or vestibule
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• uniform orientation of neighboring hair cells within the same side of the line of polarity reversal is disrupted in sporadic areas
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nervous system
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• uniform orientation of neighboring hair cells within the same side of the line of polarity reversal is disrupted in sporadic areas
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behavior/neurological
N |
• no behavioral abnormalities are seen
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd6tm1Pche mutation
(0 available);
any
Ankrd6 mutation
(117 available)
Vangl2Lp mutation
(2 available);
any
Vangl2 mutation
(34 available)
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hearing/vestibular/ear
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• patterning and polarity defects
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• coordinated orientation of the outer-most row of hair cells is disrupted
• 29.2% of the 4th row of hair cells have an orientation deviation of 30 degrees or larger from the planar cell polarity axis compared to only 0.9% of hairs in wild-type controls
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reproductive system
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• all females are sterile compared to less than 10% of mice heterozygous for Vangl2Lp alone
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nervous system
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• patterning and polarity defects
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• coordinated orientation of the outer-most row of hair cells is disrupted
• 29.2% of the 4th row of hair cells have an orientation deviation of 30 degrees or larger from the planar cell polarity axis compared to only 0.9% of hairs in wild-type controls
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