Phenotypes associated with this allele

• Allele Symbol: Ncoa4^tm1Msnt
• Allele Name: targeted mutation 1, Massimo Santoro
• Allele ID: MGI:5660201
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncoa4^tm1Msnt/Ncoa4^tm1Msnt	B6.Cg-Ncoa4^tm1Msnt	MGI:5660204

Genotype
MGI:5660204

hm1

• Allelic Composition: Ncoa4^tm1Msnt/Ncoa4^tm1Msnt
• Genetic Background: B6.Cg-Ncoa4^tm1Msnt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased fibroblast proliferation ( J:215322 )

• decrease in population doubling level in MEFs

early cellular replicative senescence ( J:215322 )

• MEFs enter replicative senescence after 4 passages

abnormal DNA replication ( J:215322 )

• replication fork speed is reduced in MEFs probably due to increased origin activation

• MEFs show increased replication fork asymmetry

homeostasis/metabolism

abnormal DNA replication ( J:215322 )

• replication fork speed is reduced in MEFs probably due to increased origin activation

• MEFs show increased replication fork asymmetry