All Phenotypes Sik1<tm1.1Berd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sik1^tm1.1Berd/Sik1^tm1.1Berd	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	MGI:5805510
cn2	Myf5^tm3(cre)Sor/Myf5⁺ Sik1^tm1.1Berd/Sik1^tm1.1Berd	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL	MGI:5805512
cn3	Sik1^tm1.1Berd/Sik1^tm1.1Berd Tg(Adipoq-cre)1Evdr/0	involves: 129S7/SvEvBrd * C57BL/6J * FVB/NJ * SJL	MGI:5805515

Allelic Composition	Sik1^tm1.1Berd/Sik1^tm1.1Berd
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sik1^tm1.1Berd mutation (0 available); any Sik1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:236223 )

• mild in mice infected with a liver-specific cre expressing adenovirus and less so than in mice with global knockout of the gene

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:236223 )

• when fed chow, mice infected with a liver-specific cre expressing adenovirus exhibit normal blood glucose when fed ad libitum or under fasted conditions and normal glucose tolerance

• when fed a high-fat diet, mice infected with a liver-specific cre expressing adenovirus exhibit normal glucose or insulin tolerance

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:236223 )

• mice fed a high fat diet exhibit elevated glucose disposal and skeletal muscle 2-deoxyglucose uptake rates compared with control mice

decreased circulating insulin level ( J:236223 )

• mice fed a high fat diet exhibit a slightly weaker insulin response to glucose compared with control mice

abnormal gluconeogenesis ( J:236223 )

• slightly reduced basal glucose production during hyperinsulinemic euglycemic clamps requiring more exogenous glucose to achieve and maintain euglycemia in mice fed a high-fat diet

improved glucose tolerance ( J:236223 )

• mice fed a high-fat diet exhibit improved glucose tolerance at late time points compared with control mice

increased insulin sensitivity ( J:236223 )

• in mice fed a high-fat diet

muscle

muscle phenotype ( J:236223 )

N	• mice exhibit grossly normal muscle structure without evidence of degeneration

increased muscle cell glucose uptake ( J:236223 )

• mice fed a high fat diet exhibit elevated skeletal muscle 2-deoxyglucose uptake rates compared with control mice

cellular

increased muscle cell glucose uptake ( J:236223 )

• mice fed a high fat diet exhibit elevated skeletal muscle 2-deoxyglucose uptake rates compared with control mice

Allelic Composition	Sik1^tm1.1Berd/Sik1^tm1.1Berd Tg(Adipoq-cre)1Evdr/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB/NJ * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sik1^tm1.1Berd mutation (0 available); any Sik1 mutation (39 available)
Tg(Adipoq-cre)1Evdr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:236223 )

N	• mice fed chow or a high-fat diet exhibit normal glucose homeostasis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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