Phenotypes associated with this allele

• Allele Symbol: Mirc32^tm1.2Jtm
• Allele Name: targeted mutation 1.2, Joshua T Mendell
• Allele ID: MGI:5648485
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc32^tm1.2Jtm/Mirc32^tm1.2Jtm	B6.129(Cg)-Mirc32^tm1.2Jtm	MGI:5707647

Genotype
MGI:5707647

hm1

• Allelic Composition: Mirc32^tm1.2Jtm/Mirc32^tm1.2Jtm
• Genetic Background: B6.129(Cg)-Mirc32^tm1.2Jtm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

colonic necrosis ( J:214382 )

• observed in DSS treated (+ 2 days recovery) mice

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:214382 )

• lamina propia myofibroblasts within the ulcers of DSS (+ 2 days recovery) treated mice are disorganized and fail to elongate along the basal-luminal axis

abnormal large intestine crypts of Lieberkuhn morphology ( J:214382 )

• intestinal crypts do not regenerate in DSS treated (+ 2 days recovery) mice

intestinal ulcer ( J:214382 )

• observed in DSS treated (+ 2 days recovery) mice

abnormal colon morphology ( J:214382 )

• colons from DSS treated (+ 2 days recovery) mice remain distended, hemorrhagic and necrotic and lack elongated, hyperproliferative crypts

colonic necrosis ( J:214382 )

• observed in DSS treated (+ 2 days recovery) mice

impaired intestine regeneration ( J:214382 )

• intestinal crypts do not regenerate in DSS treated (+ 2 days recovery) mice

• pH3+ (a mitotic marker) cells are reduced in number

increased susceptibility to induced colitis ( J:214382 )

• intestinal crypts do not regenerate in DSS treated (+ 2 days recovery) mice

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:214382 )

• intestinal crypts do not regenerate in DSS treated (+ 2 days recovery) mice

immune system

increased susceptibility to induced colitis ( J:214382 )

• intestinal crypts do not regenerate in DSS treated (+ 2 days recovery) mice

mortality/aging

abnormal susceptibility to induced morbidity/mortality ( J:214382 )

• most mice die within 2 days following the completion of 5 days (D5+2) of dextran sulfate sodium (DSS) treatment

• control mice exhibit almost complete recovery of intestinal mucosal architecture 9 days after DSS treatment