About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dohhtm1.2Sbal
targeted mutation 1.2, Stefan Balabanov
MGI:5646515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dohhtm1.2Sbal/Dohhtm1.2Sbal B6.129(Cg)-Dohhtm1.2Sbal MGI:5646517
ht2
 		Dohhtm1.2Sbal/Dohh+ B6.129(Cg)-Dohhtm1.2Sbal MGI:5646518


Genotype
MGI:5646517
hm1
Allelic
Composition		 Dohhtm1.2Sbal/Dohhtm1.2Sbal
Genetic
Background		 B6.129(Cg)-Dohhtm1.2Sbal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dohhtm1.2Sbal mutation (0 available); any Dohh mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:214321 )
• all die after E4.5 but well before E9.5




Genotype
MGI:5646518
ht2
Allelic
Composition		 Dohhtm1.2Sbal/Dohh+
Genetic
Background		 B6.129(Cg)-Dohhtm1.2Sbal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dohhtm1.2Sbal mutation (0 available); any Dohh mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen morphology ( J:214321 )
• a diffuse infiltration of the spleen with a homogenous, probably lymphoid, cell population was seen in 3 mice
• however, no significant hematological abnormalities are seen in young or adult mice

immune system
abnormal spleen morphology ( J:214321 )
• a diffuse infiltration of the spleen with a homogenous, probably lymphoid, cell population was seen in 3 mice
• however, no significant hematological abnormalities are seen in young or adult mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory