Phenotypes associated with this allele

• Allele Symbol: Srxn1^tm1Sgrh
• Allele Name: targeted mutation 1, Sue Goo Rhee
• Allele ID: MGI:5646116
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Srxn1^tm1Sgrh/Srxn1^tm1Sgrh Tg(Cyp11a1-cre)16Mchu/?	involves: C57BL/6J	MGI:5693737

Genotype
MGI:5693737

cn1

• Allelic Composition: Srxn1^tm1Sgrh/Srxn1^tm1Sgrh; Tg(Cyp11a1-cre)16Mchu/?
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating corticosterone level ( J:222986 )

• plasma levels significantly reduced

• less increase in corticosterone levels in response to ACTH

• daily oscillation in corticosterone level persists but at a lower level

increased circulating adrenocorticotropin level ( J:222986 )

• circulating ACTH levels increased 80%

endocrine/exocrine glands

adrenal gland hyperplasia ( J:222986 )

• cholesterol accumulation in steroidogenic cells

• increased number and size of vacuoles containing neutral lipids

• hyperplasia

abnormal adrenal gland secretion ( J:222986 )

• impaired steroidogenesis