Phenotypes associated with this allele

• Allele Symbol: Gpr107^tm1Brs
• Allele Name: targeted mutation 1, Brian Seed
• Allele ID: MGI:5645975
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr107^tm1Brs/Gpr107^tm1Brs	involves: 129S6/SvEvTac	MGI:5766998

Genotype
MGI:5766998

hm1

• Allelic Composition: Gpr107^tm1Brs/Gpr107^tm1Brs
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:215242 )

• homozygous mutant embryos suffer a catastrophic event and die between E11.5 and E12.5

• lethality is associated with loss of cubilin protein expression and decreased expression of multiple genes implicated in the cubilin-megalin multi-ligand endocytic receptor complex at E10.5

growth/size/body

decreased embryo size ( J:215242 )

• at E10.5, a small number of homozygous mutant embryos exhibit reduced size but are otherwise normal

embryo

decreased embryo size ( J:215242 )

• at E10.5, a small number of homozygous mutant embryos exhibit reduced size but are otherwise normal

cellular

abnormal vesicle-mediated transport ( J:215242 )

• MEFs derived from E10.5 mutant embryos exhibit defects in transferrin internalization, uptake of low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) cargo, and integrin alpha5-mediated fibronectin secretion

• mutant MEFs are resistant to LRP1-dependent cholix toxin cytotoxicity and internalize LDL poorly