Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tarbp2tm1.1Dzw mutation
(0 available);
any
Tarbp2 mutation
(22 available)
Tg(tetO-Mir208a)#Dzw mutation
(0 available)
Tg(Tnnt2-cre)5Blh mutation
(1 available)
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cardiovascular system
N |
• transgenic expression of Mir208a prevents the onset of dilated cardiomyopathy in cardiac conditional knockouts of Tarbp2 and results in mice with normal heart morphology, histology, and function
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tarbp2tm1.1Dzw mutation
(0 available);
any
Tarbp2 mutation
(22 available)
Tg(Tnnt2-cre)5Blh mutation
(1 available)
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mortality/aging
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• Although homozygotes are born in normal mendelian ratio indicating no embryonic lethality, more than 80 percent of these cardiac conditional knockout homozygotes die by 4 months of age and none survive beyond 8 months of age
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cardiovascular system
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• although gross morphology of the heart is normal at 2 weeks of age, atrial dilation is found by 3 weeks of age and substantial dilation of both atrial and ventricular chambers is found by 1 month of age and is severe in the homozygotes that survive to 2 months of age, yet cardiomyocyte size appears normal
• neonatal adeno-associated virus-mediated delivery of Tarbp2 or transgenic expression of Mir208a suppresses chamber dilation, permits normal cardiac morphology and restores viability as does knockdown of Sox6, while Tnnt2-dirven viral-mediated overexpression of Sox6 recapitulates the phenotype of cardiac conditional null Tarbp2
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• by 3 weeks of age atrial dilation is found
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• by 1 month of age dilation of the ventricular chambers is also found
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• by 2 weeks of age the left ventricular fractional shortening is decreased and this drops precipitously resulting in severe systolic dysfunction by 1 month of age
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muscle
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• by 2 weeks of age the left ventricular fractional shortening is decreased and this drops precipitously resulting in severe systolic dysfunction by 1 month of age
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