All Phenotypes Nipbl<Gt(EUCE313f02)1.2Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nipbl^{Gt(EUCE313f02)1.2Hmgu}
gene trap EUCE313f02, 1.2, Helmholtz Zentrum Muenchen GmbH
MGI:5644813

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nipbl^{Gt(EUCE313f02)1.2Hmgu}/Nipbl⁺	involves: 129 * C57BL/6J * FVB/N	MGI:7490421
ht2	Nipbl^{Gt(EUCE313f02)1.2Hmgu}/Nipbl⁺	involves: 129P2/OlaHsd * CD-1	MGI:7492204
cx3	Nipbl^{Gt(EUCE313f02)1.2Hmgu}/Nipbl⁺ Wapl^tm1.2Kpfe/Wapl⁺	involves: 129 * C57BL/6J * FVB/N	MGI:7444073
cx4	Nipbl^{Gt(EUCE313f02)1.2Hmgu}/Nipbl⁺ Wapl^tm1.1Kpfe/Wapl^tm1.2Kpfe	involves: 129 * C57BL/6J * FVB/N	MGI:7490411

Allelic Composition	Nipbl^{Gt(EUCE313f02)1.2Hmgu}/Nipbl⁺
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nipbl^{Gt(EUCE313f02)1.2Hmgu} mutation (0 available); any Nipbl mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:331699 )

growth/size/body

decreased embryo size ( J:331699 )

Allelic Composition	Nipbl^{Gt(EUCE313f02)1.2Hmgu}/Nipbl⁺
Genetic Background	involves: 129P2/OlaHsd * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nipbl^{Gt(EUCE313f02)1.2Hmgu} mutation (0 available); any Nipbl mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:236978 )

• survive poorly

cardiovascular system

ostium secundum atrial septal defect ( J:236978 )

• at E17.5 in about 30% of mice

• however, no ventricular septal defect, arterial stenosis or obvious abnormalities of ventricular wall thickness are seen

small heart ( J:236978 )

• in proportion to decrease in body size

growth/size/body

decreased body size ( J:236978 )

Allelic Composition	Nipbl^{Gt(EUCE313f02)1.2Hmgu}/Nipbl⁺ Wapl^tm1.2Kpfe/Wapl⁺
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nipbl^{Gt(EUCE313f02)1.2Hmgu} mutation (0 available); any Nipbl mutation (124 available)
Wapl^tm1.2Kpfe mutation (0 available); any Wapl mutation (168 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo size ( J:331699 )

• embryos are significantly larger than mutant mice wild-type for Wapl

• partial rescue of about 24% of reduced embryo growth phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:331699 )

• none found at weaning

growth/size/body

abnormal embryo size ( J:331699 )

• embryos are significantly larger than mutant mice wild-type for Wapl

• partial rescue of about 24% of reduced embryo growth phenotype

Allelic Composition	Nipbl^{Gt(EUCE313f02)1.2Hmgu}/Nipbl⁺ Wapl^tm1.1Kpfe/Wapl^tm1.2Kpfe
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nipbl^{Gt(EUCE313f02)1.2Hmgu} mutation (0 available); any Nipbl mutation (124 available)
Wapl^tm1.1Kpfe mutation (1 available); any Wapl mutation (168 available)
Wapl^tm1.2Kpfe mutation (0 available); any Wapl mutation (168 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo size ( J:331699 )

• embryos are significantly larger than mutant mice wild-type for Wapl

• partial rescue of about 24% of reduced embryo growth phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:331699 )

• none found at weaning

growth/size/body

abnormal embryo size ( J:331699 )

• embryos are significantly larger than mutant mice wild-type for Wapl

• partial rescue of about 24% of reduced embryo growth phenotype

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